Evidence map›Paper›PMID 32629297›Full record

ArticlePsychiatry research2020

Childhood maltreatment, serotonin transporter gene, and risk for callous and unemotional traits: A prospective investigation.

Cathy Spatz Widom, Dana Miller, Xuechen Li, Derek Gordon, Linda Brzustowicz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cathy Spatz WidomPsychology Department, John Jay College and Graduate Center, City University of New York, 524W. 59th Street, New York, NY 10019, USA. Electronic address: cwidom@jjay.cuny.edu.
Dana MillerPsychology Department, John Jay College, City University of New York, 524W. 59th Street, New York, NY 10019, USA.
Xuechen LiPsychology Department, John Jay College, City University of New York, 524W. 59th Street, New York, NY 10019, USA.
Derek GordonDepartment of Genetics and Human Genetics Institute, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854-8082, USA.
Linda BrzustowiczDepartment of Genetics and Human Genetics Institute, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ, 08854-8082, USA.
City University of New York · USRutgers, The State University of New Jersey · USJohn Jay College of Criminal Justice · US

Funding

THIRTY YEAR FOLLOW-UP OF NEGLECTED CHILDRENR01HD040774 · NICHD · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI WIDOM, CATHY SPATZ · 2000 to 2009
$8.7M
Child Maltreatment and Risk for Mild Cognitive Impairment and Alzheimer's DiseaseR01AG058683 · NIA · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · PI WIDOM, CATHY SPATZ · 2018 to 2022
$7.6M
CHILDHOOD VICTIMIZATION AND LIFETIME REVICTIMIZATIONR01MH058386 · NIMH · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI WIDOM, CATHY SPATZ · 1999 to 2003
$2.8M
Genes, Behavior, Psychosocial Links of Child Maltreatment to Health, DiseaseR01HD072581 · NICHD · JOHN JAY COLLEGE OF CRIMINAL JUSTICE · PI BRZUSTOWICZ, LINDA M, WIDOM, CATHY SPATZ · 2011 to 2013
$1.3M
Child Abuse and Neglect, Chronic Stress, and Drug AbuseR01DA017842 · NIDA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI WIDOM, CATHY SPATZ · 2004 to 2005
$386k
LONGTERM MENTAL OUTCOMES OF CHILD ABUSE &NEGLECTR01MH049467 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WIDOM, CATHY SPATZ · 1992 to 1994
–
CHILD ABUSE, RISK, AND PROTECTIVE FACTORS--DRUG ABUSER01DA010060 · NIDA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WIDOM, CATHY SPATZ · 1996 to 1997
–
CHILDHOOD VICTIMIZATION AND RISK FOR ALCOHOL PROBLEMSR03AA009238 · NIAAA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI WIDOM, CATHY SPATZ · 1992 to 1993
–
CHILD ABUSE AND ALCOHOL ABUSER21AA011108 · NIAAA · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI WIDOM, CATHY SPATZ · 1997 to 1998
–
NIAAA NIH HHS R03 AA009238NIAAA NIH HHS R21 AA011108NIA NIH HHS R01 AG058683NICHD NIH HHS R01 HD040774NICHD NIH HHS R01 HD072581NIDA NIH HHS R01 DA010060NIDA NIH HHS R01 DA017842NIMH NIH HHS R01 MH049467NIMH NIH HHS R01 MH058386
6 · The paper itself

Abstract

Previous studies have reported associations between the serotonin transporter 5-HTTLPR genotype and antisocial and aggressive traits and between child maltreatment and antisocial traits. However, few studies have examined whether 5-HTTLPR moderates the influence of childhood maltreatment on callous and unemotional traits, a hallmark of psychopathy. Using a prospective cohort design, children with documented cases of maltreatment and matched controls were followed up and interviewed in adulthood. DNA was extracted from blood and saliva (N = 414) and callous-unemotional (CU) traits were assessed. Childhood maltreatment predicted higher CU scores in adulthood, whereas the effect of 5-HTTLPR was not significant. The effect of child maltreatment on CU traits did not differ by genetic risk (high or low activity 5-HTTLPR), whereas controls with the LL genotype had higher CU scores than controls with the SS genotype. Similar results were found for females and White, non-Hispanics, but not for males and Blacks. Variations in 5-HTTLPR did not affect the impact of child maltreatment on CU traits in adulthood. Genetic risk had a stronger effect on adults with lower environmental risk (controls). Having a history of child maltreatment or the LL genotype placed participants at risk for higher levels of callous and unemotional trait scores.

Indexed as

AdultAggressionChildChild AbuseChild, PreschoolConduct DisorderFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human5-HTTLPRAbuse/neglectCallous/unemotional traitsChild maltreatmentProspective cohort designSerotonin

Identifiers

PMID32629297
PMCPMC7484357
OpenAlexW3040071576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.