Evidence map›Paper›PMID 32629178›Full record

ArticleNeoplasia (New York, N.Y.)2020

BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.

Florina Grigore, Hana Yang, Nicholas D Hanson, Matthew W VanBrocklin, Aaron L Sarver, James P Robinson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Florina GrigoreThe Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
Hana YangThe Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
Nicholas D HansonThe Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
Matthew W VanBrocklinHuntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA; Department of Oncological Sciences, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA; Department of Surgery, University of Utah Health Sciences Center, Salt Lake City, Utah 84112, USA.
Aaron L SarverMasonic Cancer Center, 2231 6th St SE, Minneapolis, MN 5545, USA; Institute for Health Informatics, 420 Delaware St. SE, Minneapolis, MN 55455, USA.
James P RobinsonThe Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA; Masonic Cancer Center, 2231 6th St SE, Minneapolis, MN 5545, USA. Electronic address: Robinsoj@umn.edu.
University of Minnesota · USMinnesota Department of Health · USUniversity of Utah · US

Funding

Bioinformatics approaches to solve the "Missing Driver" problem in solid tumorsR50CA211249 · NCI · UNIVERSITY OF MINNESOTA · PI SARVER, AARON L · 2016 to 2020
$565k
NCI NIH HHS R50 CA211249
6 · The paper itself

Abstract

The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAF

Indexed as

AnimalsApoptosisCell ProliferationCyclin-Dependent Kinase Inhibitor p16Drug Resistance, NeoplasmFemaleHistone MethyltransferasesHistonesMaleMelanoma, ExperimentalMethylationMiceMice, KnockoutMutationProtein Kinase InhibitorsProto-Oncogene Proteins B-rafCdkn2a protein, mouseCyclin-Dependent Kinase Inhibitor p16Histone MethyltransferasesHistonesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafPTEN PhosphohydrolasePten protein, mouseBRAFHistoneMelanomaMouseResistance

Identifiers

PMID32629178
PMCPMC7338995
OpenAlexW3039031425

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.