ArticleNeuroImage. Clinical2020
Childhood assaultive trauma and physical aggression: Links with cortical thickness in prefrontal and occipital cortices.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Traumatic stress recruits an excitatory orbitofrontal-amygdala pathway to drive maladaptive aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Childhood trauma and impulsivity in children with first-episode depression: mediation by left frontopolar thickness.BMC psychiatry · 2026Article
- Resting-State Functional Connectivity Changes Associated With Post-Traumatic Stress and Anxiety Symptoms in North Korean Refugees.Psychiatry investigation · 2026Article
- Orbitofrontal functional network: the mediating role between violence and childhood trauma in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Sex Differences in the Effects of Early Life Stressors in a Rat Model of Myofascial Low Back Pain.European journal of pain (London, England) · 2025Article
- Real-time aggression in youth and its connection to region-specific structural brain alterations.Discover mental health · 2025Article
- Frontal Theta Event-Related Oscillations During a Continuous Performance Test: The Influence of Trauma Type and Fluid Intelligence Polygenic Score.Brain and behavior · 2025Article
- Common and distinct neural underpinnings of the association between childhood maltreatment and depression and aggressive behavior.BMC psychiatry · 2025Article
- Associations between childhood maltreatment and overt aggression in depressed adolescents: the mediating effect of alexithymia and insomnia.Frontiers in psychiatry · 2025Article
- Childhood adversity, stress reactivity, and structural brain measures in stress-related/neurodevelopmental disorders, and their comorbidity: A large transdiagnostic cross-sectional study.Human brain mapping · 2024Article
- Executive dysfunction and cortical variations among intimate partner violence perpetrators and the association with sexism.Social cognitive and affective neuroscience · 2024Article
- Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals.Journal of psychopathology and clinical science · 2023Article
- Clarifying the synergistic effects of emotion dysregulation and inhibitory control on physical aggression.Human brain mapping · 2022Article
- Article
- Cortical thickness in parietal regions link perseverative thinking with suicidal ideation.Journal of affective disorders · 2022Article
- Association between parental age, brain structure, and behavioral and cognitive problems in children.Molecular psychiatry · 2022Article
- A multilevel examination of lifetime aggression: integrating cortical thickness, personality pathology and trauma exposure.Social cognitive and affective neuroscience · 2021Article
- Distinctive Frontal and Occipitotemporal Surface Features in Neglectful Parenting.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although the link between childhood maltreatment and violence perpetration in adulthood (i.e., the "cycle of violence") is well-documented, the neural mechanisms driving these processes remain relatively unknown. The objectives of this study were to investigate whether cortical thickness in adulthood varies as a function of childhood assaultive trauma exposure and whether such neurobiological markers of early trauma relate to the perpetration of aggression across the lifespan. In a sample of 138 ethnically-diverse men and women, whole-brain analysis of the cortical mantle revealed that individuals with exposure to assaultive trauma before age 13 had less cortical thickness in two clusters that survived multiple comparison correction: a region that peaked in the left lateral orbitofrontal cortex (OFC) and a region peaking in the right pericalcarine cortex. Diminished cortical thickness in the left OFC cluster was, in turn, associated with greater physical aggression, and mediation analysis revealed that reductions in cortical thickness in this left prefrontal region partially accounted for the association between exposure to childhood assaultive trauma and lifetime perpetration of aggression in adulthood. Findings extend previous investigations into the morphological correlates of early assaultive trauma by implicating reductions in cortical thickness as a potential mechanism linking early violence exposure to violence perpetration that extends into adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.