ArticleCellular and molecular gastroenterology and hepatology2020
Helminth-Induced and Th2-Dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High-Fat Diet.
Article in Cellular and molecular gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Helminth Infection, Gut Microbiome Alterations, and Their Impact on Pulmonary Tuberculosis Susceptibility.Journal of tropical medicine · 2026Review
- Gut Permeability and Microbiota in Parkinson's Disease: Mechanistic Insights and Experimental Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Breaking down barriers: is intestinal mucus degradation byInfection and immunity · 2025Review
- Aging impairs type 2 immune responses to nematodes associated with reduced gut microbiota responsiveness.Scientific reports · 2025Article
- Clinical challenges and technological breakthroughs in helminthic therapy for diabetes.Frontiers in immunology · 2025Review
- Intestinal helminthFrontiers in microbiology · 2025Article
- Article
- Helminth-induced immune modulation in colorectal cancer: exploring therapeutic applications.Frontiers in immunology · 2025Review
- Effect ofACS pharmacology & translational science · 2024Article
- Gut microbiota: a crucial player in the combat against tuberculosis.Frontiers in immunology · 2024Review
- Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation.NPJ biofilms and microbiomes · 2023Article
- Networking between helminths, microbes, and mammals.Cell host & microbe · 2023Review
- Maternal helminth infection protects offspring from high-fat-diet-induced obesity through altered microbiota and SCFAs.Cellular & molecular immunology · 2023Article
- Helminth egg derivatives as proregenerative immunotherapies.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Characteristic alterations of gut microbiota in uncontrolled gout.Journal of microbiology (Seoul, Korea) · 2022Article
- Helminths and Bacterial Microbiota: The Interactions of Two of Humans' "Old Friends".International journal of molecular sciences · 2022Review
- Helminth infection modulates number and function of adipose tissue Tregs in high fat diet-induced obesity.PLoS neglected tropical diseases · 2022Article
- Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics.Frontiers in parasitology · 2022Review
- Obesity-Mediated Immune Modulation: One Step Forward, (Th)2 Steps Back.Frontiers in immunology · 2022Review
- Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsEpidemiological and animal studies have indicated an inverse correlation between the rising prevalence of obesity and metabolic syndrome and exposure to helminths. Whether helminth-induced immune response contributes to microbiota remodeling in obesity remains unknown. The aim of this study is to explore the immune-regulatory role of helminth in the prevention of HFD-induced obesity through remodeling gut microbiome.
methodsC57BL/6J WT and STAT6
resultsHelminth infection of STAT6
conclusionOur findings provide new mechanistic insights into the complex interplay between helminth infection, the immune system and the gut microbiota in a HFD-induced obesity model and holds promise for gut microbiome-targeted immunotherapy in obesity prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.