Observational studyRespiratory physiology & neurobiology2020
Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2.
Observational study in Respiratory physiology & neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05178160 (Lung Ultrasound-Guided PEEP Titration Versus Standard Protocol in Patients With COVID-19 ARDS Treated With CPAP), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Ultrasound-Guided PEEP Titration Versus Standard Protocol in Patients With COVID-19 ARDS Treated With CPAP: a Single Center Prospective Trial
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effect of non-invasive ventilation and high-flow nasal cannula on hospital mortality in COVID-19-induced acute respiratory failure: a meta-analysis.Einstein (Sao Paulo, Brazil) · 2026Pooled it
- The use of non-invasive ventilation in COVID-19: A systematic review.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- Pooled it
- The Role of POCUS to Face COVID-19: A Narrative Review.Journal of clinical medicine · 2024Review
- Use of CPAP Ventilation in Non-ICU Wards May Influence Outcomes in Patients with Severe Respiratory COVID-19.Medicina (Kaunas, Lithuania) · 2024Article
- Utilization of Continuous Positive Airway Pressure (CPAP) by Emergency Medical Services: Updated Systematic Review and Meta-analysis.Galen medical journal · 2023Article
- Semiquantitative Chest CT Severity Score Predicts Failure of Noninvasive Positive-Pressure Ventilation in Patients Hospitalized for COVID-19 Pneumonia.Journal of cardiothoracic and vascular anesthesia · 2022Observational
- Treatment of COVID-19 Acute Respiratory Distress Syndrome With a Tabletop Noninvasive Ventilation Device in a Respiratory Intermediate Care Unit.Mayo Clinic proceedings. Innovations, quality & outcomes · 2022Article
- SIMEU position paper on non-invasive respiratory support in COVID-19 pneumonia.Internal and emergency medicine · 2022Article
- Noninvasive respiratory support for acute respiratory failure due to COVID-19.Current opinion in critical care · 2022Review
- Non-invasive respiratory support in the management of acute COVID-19 pneumonia: considerations for clinical practice and priorities for research.The Lancet. Respiratory medicine · 2022Review
- COVID-19 respiratory support outside the ICU's doors. An observational study for a new operative strategy.Acta bio-medica : Atenei Parmensis · 2021Observational
- Noninvasive respiratory support and patient self-inflicted lung injury in COVID-19: a narrative review.British journal of anaesthesia · 2021Review
- The importance of genomic analysis in cracking the coronavirus pandemic.Expert review of molecular diagnostics · 2021Review
- Mechanical Ventilation and Coronavirus Disease 2019: A Case-Control Analysis of Clinical Characteristics, Lung Mechanics, and Mortality.Critical care explorations · 2021Article
- Non Invasive Respiratory Support Therapies in COVID-19 Related Acute Respiratory Failure: Looking at the Neglected Issues.Archivos de bronconeumologia · 2021Article
- Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.Critical care (London, England) · 2021Article
- Lung ultrasound as diagnostic tool for SARS-CoV-2 infection.Internal and emergency medicine · 2021Article
- A new mode of mechanical ventilation: positive + negative synchronized ventilation.Multidisciplinary respiratory medicine · 2021Article
- CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation.BMJ open respiratory research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring the COVID-19 outbreak, a very high number of infected patients developed pneumonia and many of them complicated with acute respiratory distress syndrome. The optimal management of respiratory failure and the role of lung ultrasound imaging in the evaluation of efficacy of treatment are unknown.
methodsIn March 2020 we treated 18 patients with mild and moderate ARDS secondary to SARS-CoV-2 with non-invasive continuous positive airway pressure therapy (NI-CPAP). All patients underwent lung ultrasound imaging to verify the entity of lung recruitment after NI-CPAP initiation.
resultsAfter one hour of treatment we observed a significant improvement in PaO2/FiO2 ratio in 10 patients. Notably, only 50 % of them reached an effective improvement in lung aeration detectable with lung ultrasound. In the other 50 % or patients the improvement in PaO2/FiO2 might be related to blood redistribution and reverse of hypoxic vasoconstriction.
conclusionNI- CPAP is a valid therapeutic option in mild and moderate ARDS secondary SARS-CoV-2. Lung recruitment detected by means of lung ultrasound is a relevant but not the exclusive mechanism that underlies the therapeutic efficacy of NI-CPAP in this clinical setting.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.