Evidence map›Paper›PMID 32628815›Full record

ReviewJournal of cellular and molecular medicine2020

Protective role of NRF2 in macrovascular complications of diabetes.

Junduo Wu, Xiaodan Sun, Ziping Jiang, Jun Jiang, Linlin Xu, Ao Tian, Xuechun Sun, Huali Meng, Ying Li, Wenlin Huang and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Junduo WuDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, China.
Xiaodan SunIntensive Care Unit, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ziping JiangDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
Jun JiangDepartment of Neurosurgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Linlin XuDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ao TianDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xuechun SunDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Huali MengDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ying LiDepartment of Dermatology, Affiliated Hospital of Beihua University, Jilin, China.
Wenlin HuangSchool of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA, USA.
Ye JiaBeckman Research Institute of City of Hope, Duarte, CA, USA.
Hao WuDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.ORCID 0000-0001-5738-4015
Shandong University · CNSecond Hospital of Shandong University · CNBeihua University · CNCity Of Hope National Medical Center · USGwinnett College · USJilin University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrovascular complications develop in over a half of the diabetic individuals, resulting in high morbidity and mortality. This poses a severe threat to public health and a heavy burden to social economy. It is therefore important to develop effective approaches to prevent or slow down the pathogenesis and progression of macrovascular complications of diabetes (MCD). Oxidative stress is a major contributor to MCD. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) governs cellular antioxidant defence system by activating the transcription of various antioxidant genes, combating diabetes-induced oxidative stress. Accumulating experimental evidence has demonstrated that NRF2 activation protects against MCD. Structural inhibition of Kelch-like ECH-associated protein 1 (KEAP1) is a canonical way to activate NRF2. More recently, novel approaches, such as activation of the Nfe2l2 gene transcription, decreasing KEAP1 protein level by microRNA-induced degradation of Keap1 mRNA, prevention of proteasomal degradation of NRF2 protein and modulation of other upstream regulators of NRF2, have emerged in prevention of MCD. This review provides a brief introduction of the pathophysiology of MCD and the role of oxidative stress in the pathogenesis of MCD. By reviewing previous work on the activation of NRF2 in MCD, we summarize strategies to activate NRF2, providing clues for future intervention of MCD. Controversies over NRF2 activation and future perspectives are also provided in this review.

Indexed as

AnimalsDiabetes ComplicationsDiabetes MellitusDiabetic AngiopathiesHumansNF-E2-Related Factor 2NF-E2-Related Factor 2complicationsdiabetesmacrovascularNRF2oxidative stress

Identifiers

PMID32628815
PMCPMC7417734
OpenAlexW3039602953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.