ArticlePLoS pathogens2020
Pyrrocidine, a molecular off switch for fumonisin biosynthesis.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Transcriptomic Analysis ofMicroorganisms · 2026Article
- Tangeretin Suppresses Fumonisin Production by Modulating an NmrA- and HSCARG-like Protein inJournal of fungi (Basel, Switzerland) · 2025Article
- The palmitoyl-CoA ligase Fum16 is part of amBio · 2025Article
- Trichothecenes and Fumonisins: Key Players inToxins · 2024Review
- Fungal chemical warfare: the role of aflatoxin and fumonisin in governing the interaction between the maize pathogens,Frontiers in cellular and infection microbiology · 2024Article
- Pyrrocidines A and B demonstrate synergistic inhibition ofFrontiers in microbiology · 2024Article
- Development of a fumonisin-sensitiveApplied and environmental microbiology · 2023Article
- The Role of Mycotoxins in Interactions betweenToxins · 2023Article
- Microbiota of maize kernels as influenced byFrontiers in microbiology · 2023Article
- Fungal and mycotoxin contaminants in cannabis and hemp flowers: implications for consumer health and directions for further research.Frontiers in microbiology · 2023Review
- Identification of Genetic Diversity, Pyrrocidine-Producing Strains and Transmission Modes of EndophyticMicroorganisms · 2022Article
- Transcriptomic Response ofFrontiers in fungal biology · 2022Article
- Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants.Frontiers in plant science · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarocladium zeae is a fungal endophyte of maize and can be found co-inhabiting a single seed with Fusarium verticillioides, a major mycotoxigenic food safety threat. S. zeae produces pyrrocidines A and B that inhibit the growth of F. verticillioides and may limit its spread within the seed to locations lacking S. zeae. Although coinhabiting single seeds, the fungi are generally segregated in separate tissues. To understand F. verticillioides' protective physiological response to pyrrocidines we sequenced the F. verticillioides transcriptome upon exposure to purified pyrrocidine A or B at sub-inhibitory concentrations. Through this work we identified a F. verticillioides locus FvABC3 (FVEG_11089) encoding a transporter critical for resistance to pyrrocidine. We also identified FvZBD1 (FVEG_00314), a gene directly adjacent to the fumonisin biosynthetic gene cluster that was induced several thousand-fold in response to pyrrocidines. FvZBD1 is postulated to act as a genetic repressor of fumonisin production since deletion of the gene resulted in orders of magnitude increase in fumonisin. Further, pyrrocidine acts, likely through FvZBD1, to shut off fumonisin biosynthesis. This suggests that S. zeae is able to hack the secondary metabolic program of a competitor fungus, perhaps as preemptive self-protection, in this case impacting a mycotoxin of central concern for food safety.
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