Evidence map›Paper›PMID 32628542›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Upregulated proteoglycan-related signaling pathways in fluid flow shear stress-treated podocytes.

Tarak Srivastava, Trupti Joshi, Yuexu Jiang, Daniel P Heruth, Mohamed H Rezaiekhaligh, Jan Novak, Vincent S Staggs, Uri S Alon, Robert E Garola, Ashraf El-Meanawy and 6 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. PIEZO1-Mediated Calcium Signaling and Podocyte Injury in Diabetic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Tarak SrivastavaSection of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.
Trupti JoshiDepartment of Health Management and Informatics and University of Missouri Informatics Institute, University of Missouri, Columbia, Missouri.
Yuexu JiangDepartment of Electrical Engineering and Computer Science, University of Missouri, Columbia, Missouri.
Daniel P HeruthChildren's Mercy Research Institute, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.
Mohamed H RezaiekhalighSection of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.
Jan NovakDepartment of Microbiology, University of Alabama, Birmingham, Alabama.
Vincent S StaggsBiostatistics and Epidemiology Core, Children's Mercy Kansas City, Department of Pediatrics, University of Missouri, Kansas City, Missouri.
Uri S AlonSection of Nephrology, Children's Mercy Hospital and University of Missouri, Kansas City, Missouri.
Robert E GarolaDepartment of Pathology and Laboratory Medicine, Children's Mercy Hospital and University of Missouri, Kansas City.
Ashraf El-MeanawyDivision of Nephrology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Ellen T McCarthyKidney Institute, University of Kansas Medical Center, Kansas City, Kansas.
Jianping ZhouMidwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Varun C BoinpellyMidwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Ram SharmaMidwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Virginia J SavinMidwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Mukut SharmaMidwest Veterans' Biomedical Research Foundation, Kansas City, Missouri.
Biomedical Research Foundation · USChildren's Mercy Hospital · USUniversity of Missouri · USVeterans Health Administration · USMedical College of Wisconsin · USMercy Hospital · USMRIGlobal · USUniversity of Alabama at Birmingham · USUniversity of Kansas Medical Center · USUniversity of Missouri–Kansas City · US

Funding

Targeting PGE2 Receptors to attenuate shear stress-induced glomerular injuryR01DK107490 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI SRIVASTAVA, TARAK · 2016 to 2020
$2.0M
CYTOCHROME P-450 AND GLOMERULAR PROTEIN PERMEABILITYR01DK064969 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MCCARTHY, ELLEN T · 2005 to 2010
$1.7M
BLRD VA I01 BX001037HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK064969HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK107490NIDDK NIH HHS R01 DK064969NIDDK NIH HHS R01 DK107490U.S. Department of Veterans Affairs (VA) BX001037
6 · The paper itself

Abstract

The ultrafiltrate flow over the major processes and cell body generates fluid flow shear stress (FFSS) on podocytes. Hyperfiltration-associated increase in FFSS can lead to podocyte injury and detachment. Previously, we showed that FFSS-induced upregulation of the cyclooxygenase 2 (COX2)-PGE

Indexed as

Stress, MechanicalCyclooxygenase 2Kidney GlomerulusMechanotransduction, CellularPodocytesProteoglycansReceptors, Prostaglandin E, EP2 SubtypeTOR Serine-Threonine KinasesTranscriptional ActivationUp-RegulationCyclooxygenase 2ProteoglycansReceptors, Prostaglandin E, EP2 SubtypeTOR Serine-Threonine Kinasesfluid flow shear stressgalactose metabolismglycocalyxhyperfiltrationIntegrative MultiOmics Pathway Resolutionpodocytes

Identifiers

PMID32628542
PMCPMC7473905
OpenAlexW3038350218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.