Evidence map›Paper›PMID 32628505›Full record

ArticleCirculation. Arrhythmia and electrophysiology2020

Late I

Jungmin Hwang, Tae Yun Kim, Dmitry Terentyev, Mingwang Zhong, Anatoli Y Kabakov, Peter Bronk, Karuppiah Arunachalam, Luiz Belardinelli, Sridharan Rajamani, Yukiko Kunitomo and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Current and future precision therapy approaches in the long QT syndrome.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2025
    Article
  4. Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024
    Article
  5. 25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Review
  6. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  7. Article
  8. Improved CaJournal of molecular and cellular cardiology · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Jungmin HwangCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Tae Yun KimCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Dmitry TerentyevCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Mingwang ZhongDepartment of Physics, Northeastern University, Boston, MA (M.Z., A.K.).
Anatoli Y KabakovCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Peter BronkCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Karuppiah ArunachalamCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Luiz BelardinelliDepartment of Biology, Gilead Science, Foster City, CA (L.B., S.R.).
Sridharan RajamaniDepartment of Biology, Gilead Science, Foster City, CA (L.B., S.R.).
Yukiko KunitomoCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Zachary PfeifferCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Yichun LuCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Xuwen PengDepartment of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey (X.P.).
Katja E OdeningDepartment of Cardiology & Angiology I, Heart Center, University of Freiburg, Germany (K.E.O.).
Zhilin QuDepartment of Medicine, University of California, Los Angeles (Z.Q.).
Alain KarmaDepartment of Physics, Northeastern University, Boston, MA (M.Z., A.K.).
Gideon KorenCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Bum-Rak ChoiCardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (J.H., T.Y.K., D.T., A.Y.K., P.B., K.A., Y.K., Z.P., Y.L., G.K., B.-R.C.).
Brown University · USNortheastern University · USAmgen (United States) · USGilead Sciences (United States) · USPennsylvania State University · USUniversity of California, Los Angeles · USUniversity of Freiburg · DEUniversity of Rhode Island · US

Funding

A Multi-Scale Approach to Cardiac Arrhythmia: from the Molecule to the OrganR01HL110791 · NHLBI · RHODE ISLAND HOSPITAL · PI KOREN, GIDEON · 2013 to 2017
$7.3M
Mitochondria and arrhythmogenic calicum cycling dynamics in the heartR01HL133294 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN, XIE, LAI-HUA · 2017 to 2020
$2.8M
REgulation of Calcium Homeostasis by MyomiRs in Heart FailureR01HL121796 · NHLBI · RHODE ISLAND HOSPITAL · PI TERENTYEV, DMITRY A · 2015 to 2019
$2.0M
A population-based in silico platform for arrhythmia predictionR01HL134709 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI QU, ZHILIN · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL110791NHLBI NIH HHS R01 HL121796NHLBI NIH HHS R01 HL133294NHLBI NIH HHS R01 HL134709
6 · The paper itself

Abstract

backgroundLong QT syndrome has been associated with sudden cardiac death likely caused by early afterdepolarizations (EADs) and polymorphic ventricular tachycardias (PVTs). Suppressing the late sodium current (I

methodsWe tested the effects of the selective I

resultsGS967 reduced ventricular fibrillation induction under a rapid pacing protocol (n=7/14 hearts in control versus 1/14 hearts at 100 nmol/L) without altering action potential duration or restitution and dispersion. GS967 suppressed PVT incidences by reducing Ca

conclusionsSelective I

Indexed as

Action PotentialsAnimalsAnimals, Genetically ModifiedAnti-Arrhythmia AgentsCalcium SignalingComputer SimulationDelayed Rectifier Potassium ChannelsDisease Models, AnimalFemaleHeart RateLong QT SyndromeMaleModels, CardiovascularMyocytes, CardiacPyridinesRabbits6-(4-(trifluoromethoxy)phenyl)-3-(trifluoromethyl)(1,2,4)triazolo(4,3-a)pyridineAnti-Arrhythmia AgentsDelayed Rectifier Potassium ChannelsPyridinesSodium-Calcium ExchangerSodium Channel BlockersSodium ChannelsTriazoleselectrophysiologylong QT syndromepotassium channelssodium channelsventricular fibrillation

Identifiers

PMID32628505
PMCPMC10626560
OpenAlexW3039632216

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.