ArticleAnnals of clinical and translational neurology2020
Cognitive impairment in patients with Neuro-Sjögren.
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- When Dryness Extends to the Brain: Brain-Related Non-Sicca Manifestations of Sjögren's Disease.Journal of clinical medicine · 2026Review
- Beyond Dryness: Mapping the Psychological and Cognitive Burden in Sjögren's Disease-A Narrative Review.Journal of clinical medicine · 2026Review
- Effects of cognitive-motor dual-task walking on gait and pain in primary Sjögren's syndrome: a comparative cross-sectional study.Clinical rheumatology · 2026Article
- Review
- Idiopathic inflammatory myopathy associated with Sjögren's disease: features of a distinct clinical entity.Frontiers in immunology · 2025Article
- [Update on Sjögren's syndrome : Diagnostics, treatment, and challenges].Zeitschrift fur Rheumatologie · 2024Article
- Sjögren's syndrome with and without neurological involvement.Journal of neurology · 2023Article
- Saliva Free Light Chains in Patients with Neuro-Sjögren.Biomedicines · 2022Article
- Smell and Taste Function and Their Disturbances in Sjögren's Syndrome.International journal of environmental research and public health · 2022Review
- Trigeminal Nerve Affection in Patients with Neuro-Sjögren Detected by Corneal Confocal Microscopy.Journal of clinical medicine · 2022Article
- The interplay between cognition, depression, anxiety, and sleep in primary Sjogren's syndrome patients.Scientific reports · 2022Article
- Hospitalization Risks for Neurological Disorders in Primary Sjögren's Syndrome Patients.Journal of clinical medicine · 2022Article
- Fewer neurocognitive deficits and less brain atrophy by third ventricle measurement in PLWH treated with modern ART: A prospective analysis.Frontiers in neurology · 2022Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveExtraglandular neurological manifestations of Sjögren's syndrome are increasingly recognized, defining the disease entity of Neuro-Sjögren. Neuropsychological assessment of patients with Sjögren's syndrome has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety of prevalence rates for cognitive impairment (22-80%), while variable cut-off criteria for detection of cognitive impairment were applied. Attentional functions have not yet been thoroughly investigated in these patients, although they clearly represent relevant aspects of cognitive functioning in daily life.
methodsWe therefore conducted extensive neuropsychological assessment based on two neuropsychological test batteries [i.e., the extended German version of the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-PLUS), and the test battery for attentional performance (TAP) as a well-established assessment of attentional functions in the German-speaking part of Europe].
resultsSixty-four patients with Neuro-Sjögren, who were treated at our university hospital between December 2016 and January 2019, were included. Evidence for the presence of cognitive impairment was found in 55% of patients with Neuro-Sjögren. The degree of cognitive impairment ranged from mild (38%) to severe (17%). Attentional and mnemonic subtests showed pronounced cognitive impairment in patients with Neuro-Sjögren.
interpretationOur results suggest that a substantial proportion of patients with Neuro-Sjögren suffer from cognitive impairment, putatively as a corollary of attentional deficits, which might exert adverse effects on occupational abilities, other cognitive functions, and social role functioning.
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