ArticleVeterinary dermatology2020
A moisturizer formulated with glycerol and propylene glycol accelerates the recovery of skin barrier function after experimental disruption in dogs.
Article in Veterinary dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Evaluation of the Interest in and Tolerance of a Topical Emollient in the Management of Canine Nasal Hyperkeratosis: An Open-Label, Prospective, Uncontrolled Pilot Study.Veterinary sciences · 2025Article
- Expression of an epidermal growth factor-transdermal peptide fusion protein inFrontiers in plant science · 2025Article
- Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver.The AAPS journal · 2024Article
- Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle-A Narrative Review.Veterinary sciences · 2023Review
- Sphingomyelin-Rich Lipid Extract Collar for Canine Atopic Dermatitis.Veterinary sciences · 2023Article
- Effect of indoor house dust mite concentration on canine atopic dermatitis.Frontiers in veterinary science · 2023Article
- Skin Barrier Reinforcement Effect Assessment of a Spot-on Based on Natural Ingredients in a Dog Model of Tape Stripping.Veterinary sciences · 2022Article
- In vivo evaluation of the toxicity, genotoxicity, histopathological, and anti-inflammatory effects of the purified bioglycerol byproduct in biodiesel industry.Journal, genetic engineering & biotechnology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMoisturizers are foundational therapies for human atopic dermatitis. In veterinary medicine, the use of moisturizers has been recommended by an expert committee to alleviate skin dryness that would occur, for example, in canine atopic dermatitis (cAD). However, little is known regarding the effects of moisturizers on the skin barrier. HYPOTHESIS/
objectivesTo investigate the effects of a moisturizer on skin barrier recovery in a canine model of chronic mechanical barrier disruption. ANIMALS: Six healthy beagle dogs maintained in a laboratory setting. METHODS AND MATERIALS: A model of chronic skin barrier disruption was simulated by tape stripping on both sides of the thorax. The moisturizer then was applied twice daily for one week to one side of the thorax, while the other hemithorax was left untreated. The effects were evaluated by measurement of transepidermal water loss (TEWL) at various times during skin barrier recovery, and by histological assessment of the disrupted skin one week after moisturizer application.
resultsOverall, TEWL was reduced, epidermal thickness was lower, stratum corneum thickness was greater and the intensity of the dermal inflammatory infiltrate was reduced for treated sites. CONCLUSIONS AND CLINICAL IMPORTANCE: These results suggest a potential benefit of the moisturizer for improving skin barrier function, which is frequently altered in chronic inflammatory dermatoses such as cAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.