ArticleeLife2020
Stable and dynamic representations of value in the prefrontal cortex.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 57 citations in OpenAlex.
- A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice.bioRxiv : the preprint server for biology · 2026Article
- Facial gestures are enacted through a cortical hierarchy of dynamic and stable codes.Science (New York, N.Y.) · 2026Article
- Network dynamics underlying activity-timescale differences between cortical regions.bioRxiv : the preprint server for biology · 2025Article
- Out of the single-neuron straitjacket: Neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding.The Journal of physiology · 2025Article
- Learning Temporal Relationships Between Symbols with Laplace Neural Manifolds.Computational brain & behavior · 2025Article
- Ramping dynamics in the frontal cortex unfold over multiple timescales during motor planning.Journal of neurophysiology · 2025Article
- A transient high-dimensional geometry affords stable conjunctive subspaces for efficient action selection.Nature communications · 2024Article
- Rational inattention in neural coding for economic choice.bioRxiv : the preprint server for biology · 2024Article
- A Transient High-dimensional Geometry Affords Stable Conjunctive Subspaces for Efficient Action Selection.bioRxiv : the preprint server for biology · 2024Article
- Neural representational geometries reflect behavioral differences in monkeys and recurrent neural networks.Nature communications · 2024Article
- Review
- Orbitofrontal high-gamma reflects spike-dissociable value and decision mechanisms.bioRxiv : the preprint server for biology · 2024Article
- Ramping Dynamics in the Frontal Cortex Unfold Over Multiple Timescales During Motor Planning.bioRxiv : the preprint server for biology · 2024Article
- Sequential neuronal processing of number values, abstract decision, and action in the primate prefrontal cortex.PLoS biology · 2024Article
- An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024Article
- Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases.Nature communications · 2024Article
- Positive correlation between measures of habitual responding and motivated responding in mice.Journal of the experimental analysis of behavior · 2024Article
- Static and dynamic coding in distinct cell types during associative learning in the prefrontal cortex.Nature communications · 2023Article
- Behavioral read-out from population value signals in primate orbitofrontal cortex.Nature neuroscience · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Optimal decision-making requires that stimulus-value associations are kept up to date by constantly comparing the expected value of a stimulus with its experienced outcome. To do this, value information must be held in mind when a stimulus and outcome are separated in time. However, little is known about the neural mechanisms of working memory (WM) for value. Contradicting theories have suggested WM requires either persistent or transient neuronal activity, with stable or dynamic representations, respectively. To test these hypotheses, we recorded neuronal activity in the orbitofrontal and anterior cingulate cortex of two monkeys performing a valuation task. We found that features of all hypotheses were simultaneously present in prefrontal activity, and no single hypothesis was exclusively supported. Instead, mixed dynamics supported robust, time invariant value representations while also encoding the information in a temporally specific manner. We suggest that this hybrid coding is a critical mechanism supporting flexible cognitive abilities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.