Evidence map›Paper›PMID 32627966›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2020

Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-like Vasculopathy in KLF5

Kouki Nakamura, Takashi Taniguchi, Megumi Hirabayashi, Takashi Yamashita, Ryosuke Saigusa, Shunsuke Miura, Takehiro Takahashi, Tetsuo Toyama, Yohei Ichimura, Ayumi Yoshizaki and 5 more

Open access · greenAbstract read
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis.International journal of general medicine · 2022
    Review
  9. Article
  10. Endothelial-to-mesenchymal transition in systemic sclerosis.Clinical and experimental immunology · 2021
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Kouki NakamuraUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takashi TaniguchiUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Megumi HirabayashiUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takashi YamashitaUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Ryosuke SaigusaUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Shunsuke MiuraUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Takehiro TakahashiUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Tetsuo ToyamaUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Yohei IchimuraUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Ayumi YoshizakiUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0002-8194-9140
Maria TrojanowskaArthritis Center, Boston University Medical Center, Boston, Massachusetts.ORCID 0000-0001-9550-7178
Katsuhito FujiuUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Ryozo NagaiCenter for Molecular Medicine, Jichi Medical University, Tochigi, Japan.
Shinichi SatoUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.
Yoshihide AsanoUniversity of Tokyo Graduate School of Medicine, Tokyo, Japan.ORCID 0000-0001-5560-9778
The University of Tokyo · JPBoston University · USJichi Medical University · JP

Funding

The molecular mechanisms of fibrosisR01AR042334 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TROJANOWSKA, MARIA · 1994 to 2018
$5.2M
NIAMS NIH HHS R01 AR042334
6 · The paper itself

Abstract

objectiveIn prevous studies, we established a new animal model, KLF5

methodsNeovascularization and angiogenesis were assessed in KLF5

resultsNeovascularization was diminished in skin-embedded Matrigel plugs from KLF5

conclusionThe characteristics observed in the KLF5

Indexed as

AnimalsDisease Models, AnimalEndothelial CellsKruppel-Like Transcription FactorsMesenchymal Stem CellsMiceMice, KnockoutNeovascularization, PathologicProto-Oncogene Protein c-fli-1Scleroderma, SystemicVasculitisFli1 protein, mouseKlf5 protein, mouseKruppel-Like Transcription FactorsProto-Oncogene Protein c-fli-1

Identifiers

PMID32627966
PMCPMC7722222
OpenAlexW3039104783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.