ArticleAngewandte Chemie (International ed. in English)2020
Intracellular Ruthenium-Promoted (2+2+2) Cycloadditions.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
- Synthesis and Optical Properties of Diboron Complexes of 1,4-Anthraquinone Derivatives.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
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- Fluorescent Carbazole-Derived Aza[5]Helicenes: Synthesis, Functionalization, and Characterization.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Metal-Catalyzed Abiotic Cleavage of C═C Bonds for Effective Fluorescence Imaging of Cu(II) and Fe(III) in Living Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Intracellular Synthesis of Indoles Enabled by Visible-Light Photocatalysis.Journal of the American Chemical Society · 2024Article
- Variations in Intracellular Organometallic Reaction Frequency Captured by Single-Molecule Fluorescence Microscopy.Angewandte Chemie (International ed. in English) · 2023Article
- Ruthenium-catalyzed intermolecular alkene-alkyne couplings in biologically relevant media.Chemical science · 2023Article
- Metal complexes for catalytic and photocatalytic reactions in living cells and organisms.Chemical science · 2023Review
- Exporting Homogeneous Transition Metal Catalysts to Biological Habitats.European journal of organic chemistry · 2022Review
- Organometallic catalysis in aqueous and biological environments: harnessing the power of metal carbenes.Chemical science · 2022Review
- Synthetic prodrug design enables biocatalytic activation in mice to elicit tumor growth suppression.Nature communications · 2022Article
- Article
- Exporting Metal-Carbene Chemistry to Live Mammalian Cells: Copper-Catalyzed Intracellular Synthesis of Quinoxalines Enabled by N-H Carbene Insertions.Angewandte Chemie (International ed. in English) · 2021Article
- In situ activation of therapeutics through bioorthogonal catalysis.Advanced drug delivery reviews · 2021Review
- Bioorthogonal Azide-Thioalkyne Cycloaddition Catalyzed by Photoactivatable Ruthenium(II) Complexes.Angewandte Chemie (International ed. in English) · 2021Article
- Tools and Methods for Investigating Synthetic Metal-Catalyzed Reactions in Living Cells.ACS catalysis · 2021Article
- Ruthenium-Catalyzed Cycloadditions to Form Five-, Six-, and Seven-Membered Rings.Chemical reviews · 2021Review
- Tracking Reactions of Asymmetric Organo-Osmium Transfer Hydrogenation Catalysts in Cancer Cells.Angewandte Chemie (International ed. in English) · 2021Article
- Article
- Intracellular Ruthenium-Promoted (2+2+2) Cycloadditions.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metal-mediated intracellular reactions are becoming invaluable tools in chemical and cell biology, and hold promise for strongly impacting the field of biomedicine. Most of the reactions reported so far involve either uncaging or redox processes. Demonstrated here for the first time is the viability of performing multicomponent alkyne cycloaromatizations inside live mammalian cells using ruthenium catalysts. Both fully intramolecular and intermolecular cycloadditions of diynes with alkynes are feasible, the latter providing an intracellular synthesis of appealing anthraquinones. The power of the approach is further demonstrated by generating anthraquinone AIEgens (AIE=aggregation induced emission) that otherwise do not go inside cells, and by modifying the intracellular distribution of the products by simply varying the type of ruthenium complex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.