Evidence map›Paper›PMID 32627643›Full record

Observational studyJournal of the American Heart Association2020

New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients With Left Bundle Branch Block.

Andrea Di Marco, Marcos Rodriguez, Juan Cinca, Antoni Bayes-Genis, Jose T Ortiz-Perez, Albert Ariza-Solé, Jose Carlos Sanchez-Salado, Alessandro Sionis, Jany Rodriguez, Beatriz Toledano and 6 more

Erratum issuedOpen access · goldAbstract readMulticenter StudyObservational StudyValidation Study
In one paragraph

Observational study in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Observational
  4. Article
  5. [STEMI mimics : ST elevations on ECG: alternative diagnoses to acute coronary occlusion].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Clinical characteristics and the severity of coronary atherosclerosis of different subtypes of bundle-branch block.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Andrea Di MarcoHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Marcos RodriguezHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Juan CincaCardiology Department Hospital de la Santa Creu I Sant Pau IIB-Santpau CIBERCV Universitat Autonoma de Barcelona Spain.
Antoni Bayes-GenisCardiology Department Germans Trias i Pujol University Hospital CIBERCV Badalona Spain.
Jose T Ortiz-PerezCardiology Department Hospital Clinic CIBERCV Barcelona Spain.
Albert Ariza-SoléHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Jose Carlos Sanchez-SaladoHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Alessandro SionisCardiology Department Hospital de la Santa Creu I Sant Pau IIB-Santpau CIBERCV Universitat Autonoma de Barcelona Spain.
Jany RodriguezCardiology Department Hospital Clinic CIBERCV Barcelona Spain.
Beatriz ToledanoCardiology Department Germans Trias i Pujol University Hospital CIBERCV Badalona Spain.
Pau CodinaCardiology Department Germans Trias i Pujol University Hospital CIBERCV Badalona Spain.
Eduard Solé-GonzálezCardiology Department Hospital de la Santa Creu I Sant Pau IIB-Santpau CIBERCV Universitat Autonoma de Barcelona Spain.
Monica MasottiCardiology Department Hospital Clinic CIBERCV Barcelona Spain.
Joan Antoni Gómez-HospitalHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Ángel CequierHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Ignasi AngueraHeart Disease Institute Bellvitge University Hospital Barcelona Spain.
Bellvitge University Hospital · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction (AMI) in the presence of left bundle branch block. Methods and Results A multicenter retrospective cohort study including consecutive patients with suspected AMI and left bundle branch block, referred for primary percutaneous coronary intervention between 2009 and 2018. Pre-2015 patients formed the derivation cohort (n=163, 61 with AMI); patients between 2015 and 2018 formed the validation cohort (n=107, 40 with AMI). A control group of patients without suspected AMI was also studied (n=214). Different electrocardiographic criteria were tested. A total of 484 patients were studied. A new electrocardiographic algorithm (BARCELONA algorithm) was derived and validated. The algorithm is positive in the presence of ST deviation ≥1 mm (0.1 mV) concordant with QRS polarity, in any lead, or ST deviation ≥1 mm (0.1 mV) discordant with the QRS, in leads with max (R|S) voltage (the voltage of the largest deflection of the QRS, ie, R or S wave) ≤6 mm (0.6 mV). In both the derivation and the validation cohort, the BARCELONA algorithm achieved the highest sensitivity (93%-95%), negative predictive value (96%-97%), efficiency (91%-94%) and area under the receiver operating characteristic curve (0.92-0.93), significantly higher than previous electrocardiographic rules (

Indexed as

AgedAged, 80 and overAlgorithmsBundle-Branch BlockElectrocardiographyFemaleHumansMaleMiddle AgedMyocardial InfarctionRetrospective Studiesacute myocardial infarctionelectrocardiographyleft bundle branch blockprimary percutaneous coronary intervention

Identifiers

PMID32627643
PMCPMC7660719
OpenAlexW3040643343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.