Evidence map›Paper›PMID 32627328›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.

Miia Kivipelto, Francesca Mangialasche, Heather M Snyder, Ricardo Allegri, Sandrine Andrieu, Hidenori Arai, Laura Baker, Sylvie Belleville, Henry Brodaty, Sonia M Brucki and 59 more

3 registry-linked trialsOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 337 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
337citing papers in PubMed, 4 pooled it
38.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05109169 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation

Multimodal METformin and FINGER Lifestyle Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia: a Phase IIb Multi-national Randomised, Controlled Trial

TypeinterventionalSponsorImperial College LondonRan2023 to 2028Enrolled600ConditionsCognitive Decline, Cognitive Impairment, DementiaArmsFINGER 2.0 multidomain lifestyle-based intervention, Self-guided multidomain lifestyle intervention
NCT05375513 narecruitingnot on this mapstarted 2023, after this paper: background citation

A Home-based Personalized Multidomain RCT from the Canadian Therapeutic Platform for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP)

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2023 to 2026Enrolled275ConditionsMild Cognitive ImpairmentArmsPMI@Home, Brain Health Pro
NCT07180147 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)

TypeobservationalSponsorMarymount UniversityRan2025 to 2031Enrolled500ConditionsAlzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
3 · Its place in the literature

Who cites it

337 citing papers in PubMed, 4 syntheses or guidelines pooled it, 494 citations in OpenAlex.

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277 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

69 authors at 20 institutions in 21 countries.

Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Francesca MangialascheDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Heather M SnyderDivision of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
Ricardo AllegriDepartment of Cognitive Neurology, FLENI, Buenos Aires, Argentina.
Sandrine AndrieuINSERM, University of Toulouse UMR1027, Toulouse, France.
Hidenori AraiNational Center for Geriatrics and Gerontology, Obu, Japan.
Laura BakerDepartment of Internal Medicine - Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Sylvie BellevilleInstitute Universitaire de Geriatrie de Montreal, Universite de Montreal, Montreal, Canada.
Henry BrodatyCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Sydney, Australia.
Sonia M BruckiDepartment of Neurology, University of São Paulo Medical School, São Paulo, SP, Brazil.
Ismael CalandriDepartment of Cognitive Neurology, FLENI, Buenos Aires, Argentina.
Paulo CaramelliDepartment of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Christopher ChenMemory Aging and Cognition Centre, National University of Singapore, Singapore, Singapore.
Howard ChertkowDivision of Medicine/Neurology, University of Toronto, Toronto, Canada.
Effie ChewDivision of Neurology, University Medicine Cluster, National University Hospital, Singapore, Singapore.
Seong H ChoiDepartment of Neurology, Inha University School of Medicine, Incheon, Korea.
Neerja ChowdharyBrain Health Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland.
Lucía CrivelliDepartment of Cognitive Neurology, FLENI, Buenos Aires, Argentina.
Rafael De La TorreIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Yifeng DuDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Tarun DuaBrain Health Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland.
Mark EspelandDepartment of Internal Medicine - Geriatrics, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Howard H FeldmanDepartment of Neurosciences, Alzheimer Disease Cooperative Study, University of California, San Diego, California, La Jolla, USA.
Maris HartmanisDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Tobias HartmannGerman Institute for Dementia Prevention (DIDP), Medical Faculty, and Department of Experimental Neurology, Saarland University, Homburg, Germany.
Megan HeffernanCentre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Sydney, Australia.
Christiani J HenryDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Chang H HongDepartment of Psychiatry, Ajou University School of Medicine, Suwon, Korea.
Krister HåkanssonDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Takeshi IwatsuboUnit for Early and Exploratory Clinical Development, The University of Tokyo Hospital, Tokyo, Japan.
Jee H JeongDepartment of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.
Gustavo Jimenez-MaggioraAlzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, California, San Diego, USA.
Edward H KooDepartments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA.
Jenni LehtisaloPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Francisco LoperaNeuroscience Group of Antioquia (GNA), Faculty of Medicine of the University of Antioquia, Medellín, Antioquia, Colombia.
Pablo Martínez-LageDepartment of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain.
Ralph MartinsSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Lefkos MiddletonThe Ageing Epidemiology Research Unit, School of Public Health, Imperial College London, London, United Kingdom.
José L MolinuevoBarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Manuel Montero-OdassoDepartment of Medicine and Biostatistics Western University, London, Ontario, Canada.
So Y MoonDepartment of Neurology, Ajou University School of Medicine, Suwon, Korea.
Kristal Morales-PérezDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Ricardo NitriniDepartment of Neurology, University of São Paulo Medical School, São Paulo, SP, Brazil.
Haakon B NygaardDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Yoo K ParkDepartment of Medical nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Suwon, Korea.
Markku PeltonenDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Chengxuan QiuAging Research Center, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Yakeel T QuirozNeuroscience Group of Antioquia (GNA), Faculty of Medicine of the University of Antioquia, Medellín, Antioquia, Colombia.
Rema RamanAlzheimer's Therapeutic Research Institute, Keck School of Medicine, University of Southern California, California, San Diego, USA.
Naren RaoDepartment of psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Vijayalakshmi RavindranathCentre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India.
Anna RosenbergDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Takashi SakuraiNational Center for Geriatrics and Gerontology, Obu, Japan.
Rosa M SalinasLaboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Philip ScheltensAlzheimer Center Amsterdam, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Gustavo SevleverDepartment of Cognitive Neurology, FLENI, Buenos Aires, Argentina.
Hilkka SoininenDepartment of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Ana L SosaLaboratory of Dementias, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.
Claudia K SuemotoDivision of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
Mikel Tainta-CuezvaDepartment of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain.
Lina VelillaNeuroscience Group of Antioquia (GNA), Faculty of Medicine of the University of Antioquia, Medellín, Antioquia, Colombia.
Yongxiang WangDepartment of Neurology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
Rachel WhitmerDivision of Epidemiology, University of California, Davis, Davis, California, USA.
Xin XuMemory Aging and Cognition Centre, National University of Singapore, Singapore, Singapore.
Lisa J BainIndependent Science Writer, Philadelphia, Pennsylvania, USA.
Alina SolomonDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Tiia NganduDivision of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Maria C CarrilloDivision of Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois, USA.
Karolinska Institutet · SEFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · ARUniversidade de São Paulo · BRUniversity of Eastern Finland · FIAjou University · KRAlzheimer's Association · USFundacion CITA Alzheimer · ESNational Center for Geriatrics and Gerontology · JPNational University Heart Centre Singapore · SGNational University of Singapore · SGShandong University · CNUniversidad de Antioquia · COUniversity of British Columbia · CAUNSW Sydney · AUWake Forest University · USWorld Health Organization · CHAmsterdam University Medical Centers · NLEdith Cowan University · AUEwha Womans University · KRFinnish Institute for Health and Welfare · FI

Funding

US POINTER Neuroimaging Ancillary StudyR01AG062689 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI LANDAU, SUSAN M · 2019 to 2025
$47.3M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D. · 2016 to 2020
$12.2M
Diabetes and the brainZ01AG007420 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2007 to 2008
$514k
CIHR 201901CNA‐417847‐CAN‐ABPI‐ 32054Intramural NIH HHS Z01 AG007420NIA NIH HHS P30 AG049638NIA NIH HHS R01 AG062689NIH HHS R01AG062689World Health Organization 001
6 · The paper itself

Abstract

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Indexed as

Exercise TherapyLife StyleAlzheimer DiseaseClinical Trials as TopicCognitionDementiaHumansResearch DesignRisk Reduction BehaviorAlzheimer's diseasecognitive impairmentdementialifestylemultidomain interventionpreventionrandomized controlled trialWorld-Wide FINGERS

Identifiers

PMID32627328
PMCPMC9527644
OpenAlexW3040597860

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.