Evidence map›Paper›PMID 32626953›Full record

ArticleInternational journal of molecular medicine2020

Exosomal microRNA‑146a derived from mesenchymal stem cells increases the sensitivity of ovarian cancer cells to docetaxel and taxane via a LAMC2‑mediated PI3K/Akt axis.

Liya Qiu, Jiakun Wang, Mei Chen, Fengyun Chen, Wenluo Tu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 120 citations in OpenAlex.

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  7. Exosomes, autophagy, and cancer: A complex triad.International journal of cancer · 2025
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liya QiuDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital, Taizhou, Zhejiang 318000, P.R. China.
Jiakun WangDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital, Taizhou, Zhejiang 318000, P.R. China.
Mei ChenDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital, Taizhou, Zhejiang 318000, P.R. China.
Fengyun ChenDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital, Taizhou, Zhejiang 318000, P.R. China.
Wenluo TuDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital, Taizhou, Zhejiang 318000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The carrier role of exosomes from human umbilical cord mesenchymal stem cells (hUCMSCs) containing microRNAs (miRNAs) has been implicated in gene and drug therapy. The aim of the present study was to investigate the role of exosomal microRNA‑146a (miR‑146a) from hUCMSCs in ovarian cancer (OC). Following the generation of docetaxel (DTX)‑resistant SKOV3 cells and taxane‑resistant A2780 cells, exosomes were isolated from hUCMSCs and added to the chemoresistant cells. Microarray analysis revealed that miR‑146a expression was upregulated in DTX/SKOV3 cells among 15 ectopically expressed miRNAs. Analysis using the StarBase and miRSearch databases demonstrated that miR‑146a targeted laminin γ2 (LAMC2), which was further verified using dual‑luciferase reporter assays. Subsequently, miR‑146a inhibitor or LAMC2 overexpression vectors were transfected into hUCMSCs or OC cells, respectively, and their effects on growth and chemoresistance in OC cells were assessed. The hUCMSC‑derived exosomes reduced cell growth and chemoresistance in OC. Furthermore, hUCMSC‑derived exosomes with miR‑146a expression knocked down increased OC cell growth and chemoresistance, which was mediated by the PI3K/Akt signaling pathway via LAMC2.

Indexed as

ApoptosisBlotting, WesternComputational BiologyEnzyme-Linked Immunosorbent AssayExosomesFemaleHumansLamininMicroRNAsOvarian NeoplasmsLAMC2 protein, humanLamininMicroRNAs

Identifiers

PMID32626953
PMCPMC7307828
OpenAlexW3033760573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.