ReviewInternational journal of molecular medicine2020
A dissection of SARS‑CoV2 with clinical implications (Review).
Review in International journal of molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Evaluation of various blood biomarkers associated with the outcomes of patients with COVID‑19 treated in intensive care units.Experimental and therapeutic medicine · 2024Article
- A Review on Role of Inflammation in Coronavirus Disease.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Hemophagocytic lymphohistiocytosis diagnosed by bone marrow trephine biopsy in living post-COVID-19 patients: case report and mini-review.Journal of molecular histology · 2022Review
- Article
- Clinical significance of early IgA anti-SARS-CoV-2 antibody detection in patients from a Romanian referral COVID-19 hospital.Experimental and therapeutic medicine · 2022Article
- Perspectives on the Immune System in Sepsis.Maedica · 2022Article
- Social media exposure during COVID-19 lockdowns could lead to emotional overeating via anxiety: The moderating role of neuroticism.Applied psychology. Health and well-being · 2022Article
- COVID-19 in Ophthalmology. Current Disease Status and Challenges during Clinical Practice.Maedica · 2021Article
- COVID-19, cytokines, inflammation, and spices: How are they related?Life sciences · 2021Review
- Prediction of in-hospital recurrence and false-negative results in patients with COVID-19 by red blood cell values on admission.Experimental and therapeutic medicine · 2021Article
- JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy.Postgraduate medicine · 2021Review
- Role of phytoconstituents in the management of COVID-19.Chemico-biological interactions · 2021Review
- Lichen planus after SARS-CoV-2 infection treated with lopinavir/ritonavir.Medicina clinica (English ed.) · 2021Article
- Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics.Pharmaceutics · 2021Article
- Relationship between serum osteopontin levels and the severity of COVID-19 infection.Wiener klinische Wochenschrift · 2021Article
- Structure-activity relationship (SAR) and molecular dynamics study of withaferin-A fragment derivatives as potential therapeutic lead against main protease (MJournal of molecular modeling · 2021Article
- Exploitation of traditional healing properties, using the nanotechnology's advantages: The case of curcumin.Toxicology reports · 2021Article
- Article
- SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Review
- Analyzing COVID-19 virus based on enhanced fragmented biological Local Aligner using improved Ions Motion Optimization algorithm.Applied soft computing · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are being confronted with the most consequential pandemic since the Spanish flu of 1918‑1920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the naso‑pharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections: i) Clinical aspects of COVID‑19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARS‑CoV2 and proposed antiviral drugs; iii) The combination of arginine‑ascorbate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.