ArticleFrontiers in cellular and infection microbiology2020
Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites.
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Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
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- Legacy 4(1ACS infectious diseases · 2026Article
- Evolutionary remodeling of ubiquinone biosynthesis in Toxoplasma gondii reveals an essential bi-functional monooxygenase.Nature communications · 2026Article
- Concurrent Assessment of Synthetic and Natural Compounds on the Proliferation ofTropical medicine and infectious disease · 2025Article
- It Takes Two to Tango: Current Understanding of the Role of M16 Family of Proteases and Their Structural Properties.Biomolecules · 2025Review
- Comparative Hydrophobicity, Solubility, and Metabolic Stability of 4(1ACS medicinal chemistry letters · 2025Article
- TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides inbioRxiv : the preprint server for biology · 2024Article
- Factors Influencing Tissue Cyst Yield in a Murine Model of Chronic Toxoplasmosis.Infection and immunity · 2023Article
- Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bcThe Journal of biological chemistry · 2023Article
- Article
- Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM.Chemical reviews · 2022Review
- Structure-activity relationships ofExpert opinion on drug discovery · 2022Article
- Targeting the Ubiquinol-Reduction (QBiology · 2022Article
- Building Programs to Eradicate Toxoplasmosis Part IV: Understanding and Development of Public Health Strategies and Advances "Take a Village".Current pediatrics reports · 2022Review
- Building Programs to Eradicate Toxoplasmosis Part I: Introduction and Overview.Current pediatrics reports · 2022Review
- Inhibition ofFrontiers in cellular and infection microbiology · 2022Article
- Toxoplasma gondii infection and its implications within the central nervous system.Nature reviews. Microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 11 institutions in 2 countries.
Martin J McPhillieSchool of Chemistry, The University of Leeds, Leeds, United Kingdom.
Ying ZhouDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
Mark R HickmanExperimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
James A GordonSchool of Chemistry, The University of Leeds, Leeds, United Kingdom.
Christopher R WeberDepartment of Pathology, The University of Chicago, Chicago, IL, United States.
Qigui LiExperimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Patty J LeeExperimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Kangsa AmporndanaiDepartment of Biochemistry and Systems Biology, Faculty of Health and Life Sciences, Institute of Systems, Molecular and Integrative Biology, The University of Liverpool, Liverpool, United Kingdom.
Rachel M JohnsonSchool of Biomedical Sciences, Faculty of Biological Sciences, and Astbury Centre for Structural Molecular Biology, The University of Leeds, Leeds, United Kingdom.
Heather DarbySchool of Chemistry, The University of Leeds, Leeds, United Kingdom.
Stuart WoodsStrathclyde Institute of Pharmacy and Biomedical Sciences, The University of Strathclyde, Glasgow, United Kingdom.
Zhu-Hong LiDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States.
Richard S PriestleyDepartment of Tropical Disease Biology, Research Center for Drugs and Diagnostics, The Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Kurt D RistrophDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, United States.
Scott B BieringDepartment of Pathology, The University of Chicago, Chicago, IL, United States.
Kamal El BissatiDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
Seungmin HwangDepartment of Pathology, The University of Chicago, Chicago, IL, United States.
Farida Esaa HakimDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
Sarah M DovginDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
Joseph D LykinsDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
Lucy RobertsStrathclyde Institute of Pharmacy and Biomedical Sciences, The University of Strathclyde, Glasgow, United Kingdom.
Kerrie HargraveStrathclyde Institute of Pharmacy and Biomedical Sciences, The University of Strathclyde, Glasgow, United Kingdom.
Hua CongSchool of Chemistry, The University of Leeds, Leeds, United Kingdom.
Anthony P SinaiMicrobiology, Immunology and Molecular Genetics, The University of Kentucky College of Medicine, Lexington, KY, United States.
Stephen P MuenchSchool of Biomedical Sciences, Faculty of Biological Sciences, and Astbury Centre for Structural Molecular Biology, The University of Leeds, Leeds, United Kingdom.
Jitender P DubeyAnimal Parasitic Diseases Laboratory (APDL), USDA-ARS, Beltsville, MD, United States.
Robert K Prud'hommeDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, United States.
Hernan A LorenziDepartment of Infectious Diseases, J Craig Venter Institute, Rockville, MD, United States.
Giancarlo A BiaginiDepartment of Tropical Disease Biology, Research Center for Drugs and Diagnostics, The Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Silvia N MorenoDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States.
Craig W RobertsStrathclyde Institute of Pharmacy and Biomedical Sciences, The University of Strathclyde, Glasgow, United Kingdom.
Svetlana V AntonyukDepartment of Biochemistry and Systems Biology, Faculty of Health and Life Sciences, Institute of Systems, Molecular and Integrative Biology, The University of Liverpool, Liverpool, United Kingdom.
Colin W G FishwickSchool of Chemistry, The University of Leeds, Leeds, United Kingdom.
Rima McLeodDepartment of Ophthalmology and Visual Sciences, The University of Chicago, Chicago, IL, United States.
University of Chicago · USUniversity of Leeds · GBUniversity of Strathclyde · GBWalter Reed Army Institute of Research · USLiverpool School of Tropical Medicine · GBPrinceton University · USUniversity of Georgia · USUniversity of Liverpool · GBAgricultural Research Service · USJ. Craig Venter Institute · USUniversity of Kentucky · US
Funding
The J. Craig Venter Institute Genome Center for Infectious DiseasesU19AI110819 · NIAID · J. CRAIG VENTER INSTITUTE, INC. · PI TAN, GENE · 2014 to 2018
$29.7MOptimizing Inhibitors of T. gondii ENRU01AI082180 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 2009 to 2013
$4.4MTowards a Vaccine to Prevent ToxoplasmosisU01AI077887 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 2008 to 2012
$4.2MShort Term Training: Health Professional StudentsT35DK062719 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 2003 to 2017
$2.9MTREATMENT OF CONGENITAL TOXOPLASMOSISR01AI027530 · NIAID · UNIVERSITY OF CHICAGO · PI MCLEOD, RIMA L · 1989 to 2010
$2.8MInnate Immune Receptors for Toxoplasma gondiiR01AI071319 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES · 2006 to 2010
$2.7MThe Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0MQuantitative Approaches for Drug Testing in Chronic Toxoplasmosis: Leveraging New Insights Into Bradyzoite Biology Within Tissue Cysts In VivoR01AI145335 · NIAID · UNIVERSITY OF KENTUCKY · PI PATWARDHAN, ABHIJIT R., SINAI, ANTHONY P. · 2019 to 2021
$1.1MAnti-Toxoplasma isoprenoid pathway inhibitors and the host immune responseR21AI147661 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2020 to 2021
$415kMedical Research Council MC_PC_17167Medical Research Council MR/L000644/1NIAID NIH HHS HHSN272200900007CNIAID NIH HHS R01 AI027530NIAID NIH HHS R01 AI071319NIAID NIH HHS R01 AI128356NIAID NIH HHS R01 AI145335NIAID NIH HHS R21 AI147661NIAID NIH HHS U01 AI077887NIAID NIH HHS U01 AI082180NIAID NIH HHS U19 AI110819NIDDK NIH HHS T35 DK062719Wellcome TrustWellcome Trust 109158/B/15/Z
Abstract
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to improve parasite selectivity. Relative to other cytochrome
Indexed as
ParasitesToxoplasmaToxoplasmosisAnimalsMicePlasmodium falciparumcytochrome bc1nanoformulationPlasmodium falciparumRPS13Δstructure-guided designtetrahydroquinoloneToxoplasma gondiitranscriptomics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.