Evidence map›Paper›PMID 32626587›Full record

ArticleNeuro-oncology practice2020

Isocitrate dehydrogenase 1 mutant glioblastomas demonstrate a decreased rate of pseudoprogression: a multi-institutional experience.

Homan Mohammadi, Kevin Shiue, G Daniel Grass, Vivek Verma, Kay Engellandt, Dirk Daubner, Gabriele Schackert, Mercia J Gondim, Dibson Gondim, Alexander O Vortmeyer and 6 more

Open access · greenAbstract read
In one paragraph

Article in Neuro-oncology practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Homan MohammadiDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Kevin ShiueDepartment of Radiation Oncology, Indiana University Simon Cancer Center, Indianapolis, USA.
G Daniel GrassDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Vivek VermaDepartment of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA, USA.
Kay EngellandtDepartment of Neurochirurgie and Neuroradiologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
Dirk DaubnerDepartment of Neurochirurgie and Neuroradiologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
Gabriele SchackertDepartment of Neurochirurgie and Neuroradiologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.
Mercia J GondimDepartment of Pathology, Indiana University Simon Cancer Center, Indianapolis, USA.
Dibson GondimDepartment of Pathology, Indiana University Simon Cancer Center, Indianapolis, USA.
Alexander O VortmeyerDepartment of Pathology, Indiana University Simon Cancer Center, Indianapolis, USA.
Aaron P KamerDepartment of Radiation Oncology, Indiana University Simon Cancer Center, Indianapolis, USA.
William JinDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Timothy J RobinsonDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Gordon WatsonDepartment of Radiation Oncology, Indiana University Simon Cancer Center, Indianapolis, USA.
Hsiang-Hsuan M YuDepartment of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Tim LautenschlaegerDepartment of Radiation Oncology, Indiana University Simon Cancer Center, Indianapolis, USA.
Indiana University Health · USMoffitt Cancer Center · USUniversity Hospital Carl Gustav Carus · DEIndiana University – Purdue University Indianapolis · USAllegheny General Hospital · US

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Jun Wan · 1999 to 2026
$59.3M
NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

backgroundPseudoprogression (psPD) represents false radiologic evidence of tumor progression and is observed in some glioblastoma (GBM) patients after postoperative chemoradiation (CRT) with temozolomide (TMZ). The ambiguity of the psPD diagnosis confounds identification of true progression and may lead to unnecessary interventions. The association between psPD and isocitrate dehydrogenase 1 (

methodsWe retrospectively evaluated 120 patients with

resultsWithin 90 days of completing CRT, 9 GBM patients (1 [1.7%]

conclusions

Indexed as

glioblastomaisocitrate dehydrogenase 1pseudoprogressionradiation therapytemozolomide

Identifiers

PMID32626587
PMCPMC7318854
OpenAlexW2979446173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.