ReviewNeuro-oncology practice2020
A systematic review of cognitive function in patients with glioblastoma undergoing surgery.
Review in Neuro-oncology practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
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Who cites it
26 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of Glioblastoma Resection on Cognitive Function and Affective Symptoms at Three-Month Follow-Up.Brain and behavior · 2026Observational
- Multidimensional cognitive reserve and cognitive outcomes in glioblastoma: a pre- and postoperative analysis.Journal of neuro-oncology · 2026Article
- Experimental Evaluation of QY-69: A Butyrylcholinesterase Inhibitor with Anti-Glioblastoma Efficacy.Current neuropharmacology · 2026Article
- Article
- Sequential immunotherapy and bevacizumab treatments in glioblastoma multiforme: A case series and review of the literature.Oncology letters · 2025Article
- Precision Surgery for Glioblastomas.Journal of personalized medicine · 2025Review
- Brain tumor patient perceptions toward repetitive transcranial magnetic stimulation for rehabilitation after surgery.Neuro-oncology practice · 2025Article
- Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study.Journal of public health in Africa · 2025Article
- Magnetic and pH sensitive nanocomposite microspheres for controlled temozolomide delivery in glioblastoma cells.Scientific reports · 2024Article
- Whole genome sequencing in (recurrent) glioblastoma: challenges related to informed consent procedures and data sharing.Acta neurochirurgica · 2024Review
- Patient, Relative and Staff Experiences of Clinical Trial Participation in Neurooncology: "Maybe You Can Also Show the Positive, No Matter How It Ends".Cancer management and research · 2024Article
- Preoperative neurocognitive function as an independent survival prognostic marker in primary glioblastoma.Neuro-oncology practice · 2023Article
- Association between patient-reported cognitive function and location of glioblastoma.Neurosurgical review · 2023Article
- Response to Gorter et al. regarding "Acceptability and feasibility of neurocognitive assessments with adults with primary brain cancer and brain metastases: A systematic review".Neuro-oncology practice · 2023Article
- The longitudinal relation between executive functioning and multilayer network topology in glioma patients.Brain imaging and behavior · 2023Article
- Cognitive functioning in a cohort of high-grade glioma patients.Radiology and oncology · 2023Article
- Acceptability and feasibility of cognitive assessments with adults with primary brain cancer and brain metastasis: A systematic review.Neuro-oncology practice · 2023Review
- How thought itself can drive tumour growth.Nature · 2023Article
- Neurocognitive impairment, neurobehavioral symptoms, fatigue, sleep disturbance, and depressive symptoms in patients with newly diagnosed glioblastoma.Neuro-oncology practice · 2023Article
- A Prospective Study of Longitudinal Risks of Cognitive Deficit for People Undergoing Glioblastoma Surgery Using a Tablet Computer Cognition Testing Battery: Towards Personalized Understanding of Risks to Cognitive Function.Journal of personalized medicine · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with glioblastoma (GB) are more likely to suffer cognitive deficits with poor quality of life as compared with lower-grade glioma patient groups, for whom cognition research is plentiful. The objective of this systematic review is to evaluate the cognitive function of patients with GB before and after surgery.
methodsThis review was prospectively registered with PROSPERO. PubMed and EMBASE searches were performed, most recently March 15, 2018. Inclusion criteria were adult patients, histologically confirmed GB, and cognitive tests conducted before and/or after surgery. Screening and data extraction were carried out independently by 2 authors.
resultsA total of 512 abstracts were screened. Nineteen studies were included with 902 participants, of whom only 423 had histologically confirmed GB. Only 11 studies tested cognitive function both before and after surgery. A total of 114 different cognitive tests were used. The most common test was used in only 9 studies; 82 tests were used only once. Follow-up time ranged from 1 week to 16 months with extremely high dropout rates. Eighteen of 19 studies reported cognitive deficits in their samples, with prevalence ranging from 22% to 100% (median 64%, interquartile range 42%). Only 1/11 longitudinal studies reported normal cognitive function, 3/11 reported initial deficits with improvement after surgery, 3/11 reported static deficits, and 4/11 reported deterioration.
conclusionThere is a consistently high risk of cognitive deficit for patients with GB undergoing surgery. The included studies showed marked heterogeneity in study design, case-mix of included diagnoses, and the type and timing of cognitive tests used. We highlight considerations for the design of future studies to avoid such bias.
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