ArticleEFSA journal. European Food Safety Authority2018
Scientific Opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) effect models for regulatory risk assessment of pesticides for aquatic organisms.
Article in EFSA journal. European Food Safety Authority, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Current Strengths and Limitations of Toxicokinetic-Toxicodynamic (TKTD) Models for Freshwater Microalgae.Environmental science & technology · 2026Review
- Toxicokinetic-Informed Evidential Learning for Applicability-Domain-Aware QSAR/QSPR Prediction of Environmental Contaminant Toxicity.Molecules (Basel, Switzerland) · 2026Article
- A Bayesian neural ordinary differential equations framework to study the effects of chemical mixtures on survival.PLoS computational biology · 2025Article
- Combined Modeling of Multiple Exposure Routes for Terrestrial Arthropods Using the Toxicokinetic-Toxicodynamic BufferGUTS Model.Environmental science & technology · 2025Article
- MIXCOP-Implementation of a model to assess the time-dependent effects of mixed pesticides on a collembolan population.MethodsX · 2025Article
- From water to land-Usage of Generalized Unified Threshold models of Survival (GUTS) in an above-ground terrestrial context exemplified by honeybee survival data.Environmental toxicology and chemistry · 2025Article
- Comparison of visual assessment and quantitative goodness-of-fit metrics on GUTS model fits.Environmental toxicology and chemistry · 2025Article
- Advancing Maternal Transfer of Organic Pollutants across Reptiles for Conservation and Risk Assessment Purposes.Environmental science & technology · 2024Article
- Correspondence on "Mortality Pattern ofEnvironmental science & technology · 2024Article
- Mortality Pattern ofEnvironmental science & technology · 2024Article
- Toxicokinetic-Toxicodynamic Model to Assess Thermal Stress.Environmental science & technology · 2023Article
- Aquatic Risks at the Landscape Scale: A Case Study for Pyrethroid Use in Pome Fruit Orchards in Belgium.Environmental science & technology · 2023Article
- Peer review of the pesticide risk assessment of the active substance dimoxystrobin.EFSA journal. European Food Safety Authority · 2023Review
- The use of new approach methodologies for the environmental risk assessment of food and feed chemicals.Current opinion in environmental science & health · 2023Article
- hb or not hb - When and why accounting for background mortality in toxicological survival models matters?MethodsX · 2023Article
- Linking freshwater ecotoxicity to damage on ecosystem services in life cycle assessment.Environment international · 2023Review
- Modeling Time-Dependent Aquatic Toxicity of Hydrocarbons: Role of Organism Weight, Temperature, and Substance Hydrophobicity.Environmental toxicology and chemistry · 2022Article
- Explicit Consideration of Temperature Improves Predictions of Toxicokinetic-Toxicodynamic Models for Flupyradifurone and Imidacloprid inEnvironmental science & technology · 2022Article
- Statement concerning the assessment of environmental fate and behaviour and ecotoxicology in the context of the pesticides peer review of the active substance dimoxystrobin.EFSA journal. European Food Safety Authority · 2022Article
- The BEEHAVEEnvironmental toxicology and chemistry · 2022Article
Corrections and comments
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Authors and funding
29 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion on the state of the art of Toxicokinetic/Toxicodynamic (TKTD) models and their use in prospective environmental risk assessment (ERA) for pesticides and aquatic organisms. TKTD models are species- and compound-specific and can be used to predict (sub)lethal effects of pesticides under untested (time-variable) exposure conditions. Three different types of TKTD models are described, viz., (i) the 'General Unified Threshold models of Survival' (GUTS), (ii) those based on the Dynamic Energy Budget theory (DEBtox models), and (iii) models for primary producers. All these TKTD models follow the principle that the processes influencing internal exposure of an organism, (TK), are separated from the processes that lead to damage and effects/mortality (TD). GUTS models can be used to predict survival rate under untested exposure conditions. DEBtox models explore the effects on growth and reproduction of toxicants over time, even over the entire life cycle. TKTD model for primary producers and pesticides have been developed for algae,
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