Evidence map›Paper›PMID 32625166›Full record

ArticleFrontiers in endocrinology2020

Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

Katharina Mörwald, Elmar Aigner, Peter Bergsten, Susanne M Brunner, Anders Forslund, Joel Kullberg, Hakan Ahlström, Hannes Manell, Kirsten Roomp, Sebastian Schütz and 7 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Serum Ferritin and Non-alcoholic Fatty Liver Disease: A Meta-analysis and Systematic Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Katharina MörwaldDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Elmar AignerObesity Research Unit, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Peter BergstenDepartment of Medical Cell Biology, University Uppsala, Uppsala, Sweden.
Susanne M BrunnerDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Anders ForslundDepartment of Women's and Children's Health, University Uppsala, Uppsala, Sweden.
Joel KullbergDepartment of Surgical Sciences, Radiology, University Uppsala, Uppsala, Sweden.
Hakan AhlströmDepartment of Surgical Sciences, Radiology, University Uppsala, Uppsala, Sweden.
Hannes ManellDepartment of Medical Cell Biology, University Uppsala, Uppsala, Sweden.
Kirsten RoompLuxembourg Center for Systems Biomedicine, University Luxembourg, Luxembourg, Luxembourg.
Sebastian SchützDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Fanni ZsoldosDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Wilfried RennerLuxembourg Center for Systems Biomedicine, University Luxembourg, Luxembourg, Luxembourg.
Dieter FurthnerObesity Research Unit, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Katharina MaruszczakDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Stephan ZandanellObesity Research Unit, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Daniel WeghuberDepartment of Pediatrics, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria.
Harald ManggeClinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University Graz, Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Pediatric NAFLD shows unique features of histology and pathophysiology compared to adults. Changes in serum iron parameters are common in adult NAFLD and have been termed dysmetabolic iron overload syndrome characterized by increased serum ferritin levels and normal transferrin saturation; however, the associations of serum ferritin, inflammation, and liver fat content have been incompletely investigated in children. As magnetic resonance imaging (MRI) is an excellent measure for the degree of liver steatosis, we applied this method herein to clarify the interaction between ferritin and fatty liver in male adolescents. For this study, one hundred fifty male pediatric patients with obesity and who are overweight were included. We studied a subgroup of male patients with (

Indexed as

AdolescentBiomarkersBody Mass IndexCase-Control StudiesCross-Sectional StudiesFemaleFerritinsFollow-Up StudiesHumansInsulin ResistanceLiver Function TestsMaleNon-alcoholic Fatty Liver DiseasePediatric ObesityPrognosisBiomarkersFerritinsliver fat contentnon-alcocholic fatty liver diseasepediatric nonalcoholic fatty liver diseasepediatric obesityserum ferritin

Identifiers

PMID32625166
PMCPMC7314945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.