ReviewEngineering in life sciences2019
Elicitation: A biotechnological tool for enhanced production of secondary metabolites in hairy root cultures.
Review in Engineering in life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
- Chitosan activates a sequential CaPlant signaling & behavior · 2026Article
- Comparative Biochemistry of Wild and In Vitro-PropagatedLife (Basel, Switzerland) · 2026Article
- Elicitor-Mediated Enhancement of Secondary-Metabolite Biosynthesis inPlants (Basel, Switzerland) · 2026Review
- Jasmonic acid and nanoparticle elicitation ofRSC advances · 2026Article
- Integrated multi-omics analyses reveal that p-coumaroyl-CoA 2'-hydroxylases act upstream of stilbene synthases to mediate oxyresveratrol biosynthesis in mulberry (Morus alba).Plant communications · 2026Article
- Salicylic Acid Mitigates Drought-Stress-Induced Oxidative Damage inAntioxidants (Basel, Switzerland) · 2026Article
- A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights.Journal, genetic engineering & biotechnology · 2026Review
- Overproduction of tropane alkaloids in transgenic Hyoscyamus reticulatus hairy roots L. elicited by silicon dioxide nanoparticles and precursor feeding by phenylalanine and putrescine.Scientific reports · 2026Article
- Influence of salicylic acid on plant defense, growth and biochemical composition of Salix alba infected with Lymantria obfuscata in Kashmir.Scientific reports · 2026Article
- Article
- Sesquiterpene lactones in micropropagated Arnica montana shoots after elicitation-insights into metabolite accumulation and transcriptional regulation.Scientific reports · 2026Article
- Special Issue "Molecular Studies on Plant and Plant In Vitro Systems Secondary Metabolism".International journal of molecular sciences · 2026Article
- Chitosan nanoparticles as a strategy for enhancing h6h gene expression and tropane alkaloid production in Hyoscyamus reticulatus hairy roots.Scientific reports · 2025Article
- Solanum villosum Mill. an underutilized plant: establishment of hairy root culture and enhanced production of solasodine after elicitor treatment.Protoplasma · 2025Article
- Hybrid Poly(Lactic)-Chitosan Scaffold Intensifying In Situ Bioprocessing ofInternational journal of molecular sciences · 2025Article
- Biotic Elicitor-Driven Enhancement of In Vitro Micropropagation and Organogenesis inBiotech (Basel (Switzerland)) · 2025Article
- Influence of Biotic and Abiotic Elicitors on Rosmarinic Acid Accumulation in Hairy Root Cultures ofPlants (Basel, Switzerland) · 2025Article
- Enhancing the biochemical potential of holy basil through methyl jasmonate elicitation with insights into physiological responses in a plant factory.Scientific reports · 2025Article
- Stress-Induced Secondary Metabolite Profiling inInternational journal of molecular sciences · 2025Article
- Reprogramming Hairy Root Cultures: A Synthetic Biology Framework for Precision Metabolite Biosynthesis.Plants (Basel, Switzerland) · 2025Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elicitation is a possible aid to overcome various difficulties associated with the large-scale production of most commercially important bioactive secondary metabolites from wild and cultivated plants, undifferentiated or differentiated cultures. Secondary metabolite accumulation in vitro or their efflux in culture medium has been elicited in the undifferentiated or differentiated tissue cultures of several plant species by the application of a low concentration of biotic and abiotic elicitors in the last three decades. Hairy root cultures are preferred for the application of elicitation due to their genetic and biosynthetic stability, high growth rate in growth regulator-free media, and production consistence in response to elicitor treatment. Elicitors act as signal, recognized by elicitor-specific receptors on the plant cell membrane and stimulate defense responses during elicitation resulting in increased synthesis and accumulation of secondary metabolites. Optimization of various parameters, such as elicitor type, concentration, duration of exposure, and treatment schedule is essential for the effectiveness of the elicitation strategies. Combined application of different elicitors, integration of precursor feeding, or replenishment of medium or in situ product recovery from the roots/liquid medium with the elicitor treatment have showed improved accumulation of secondary metabolites due to their synergistic effect. This is a comprehensive review about the progress in the elicitation approach to hairy root cultures from 2010 to 2019 and the information provided is valuable and will be of interest for scientists working in this area of plant biotechnology.
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