ArticleEngineering in life sciences2019
Synthesis of alginate-silica hybrid hydrogel for biocatalytic conversion by β-glucosidase in microreactor.
Article in Engineering in life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Sol-Gel Synthesized Silica/Sodium Alginate Hybrids: Comprehensive Physico-Chemical and Biological Characterization.Molecules (Basel, Switzerland) · 2025Article
- Tuning Mechanical Characteristics and Permeability of Alginate Hydrogel by Polyvinyl Alcohol and Deep Eutectic Solvent Addition.Bioengineering (Basel, Switzerland) · 2024Article
- Silica-Calcium-Alginate Hydrogels for the Co-Immobilization of Glucose Oxidase and Catalase to Reduce the Glucose in Grape Must.Gels (Basel, Switzerland) · 2023Article
- Hydrogel-Based Enzyme and Cofactor Co-Immobilization for Efficient Continuous Transamination in a Microbioreactor.Frontiers in bioengineering and biotechnology · 2021Article
- Simulative Minimization of Mass Transfer Limitations Within Hydrogel-Based 3D-Printed Enzyme Carriers.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organic-inorganic hybrid materials have been used in different fields to immobilize biomolecules since they offer many advantages. The aim of this study was to optimize and characterize the alginate-silica hybrid hydrogel as a stable and injectable form for microfluidic systems using internal gelation method and increase the stability and activity of immobilized enzyme for biocatalytic conversions as well. Characterization was carried out by scanning electron microscopy, energy dispersive spectroscopy/mapping, Brunauer-Emmett-Teller, Barrett-Joyner-Halenda, and Fourier-transform infrared spectroscopy analyses, and the shrinkages of monoliths were evaluated. Subsequent to optimizing the enzyme concentration (40 μg), hydrolytic conversion of 4-nitrophenyl β-d-glucopyranoside (pNPG) was performed to understand the behavior of the bioconversion in the microfluidic system. The yield was 94% which reached the equilibrium at 24 h indicating that the alginate-silica gel derived microsystem overcome some drawbacks of monolithic systems. Additionally, bioconversion of
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