ArticleEngineering in life sciences2017
Downstream process development strategies for effective bioprocesses: Trends, progress, and combinatorial approaches.
Article in Engineering in life sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Metal-Organic Frameworks in Food Biotechnology: Opportunities, Challenges, and Future Perspectives for Probiotic Delivery, Precision Fermentation, and Circular Food Systems.Nanomaterials (Basel, Switzerland) · 2026Review
- A Comprehensive Review on the Anticancer Activity of Plant Peptides and Their Mechanisms of Action.Foods (Basel, Switzerland) · 2026Review
- Techno-economic analysis of industrial-scale fermentation for formate dehydrogenase (FDH) production.Bioresources and bioprocessing · 2025Article
- 3D Printed Microfluidic Chromatographic Column for Fast Downstream Processing Development.Biotechnology journal · 2025Article
- Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses.Analytical chemistry · 2024Article
- Review
- Yields and product comparison between Escherichia coli BL21 and W3110 in industrially relevant conditions: anti-c-Met scFv as a case study.Microbial cell factories · 2023Article
- Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver.PloS one · 2023Article
- Review
- Bioproduced Proteins On Demand (Bio-POD) in hydrogels usingBioactive materials · 2021Article
- Purification of Modified Therapeutic Proteins Available on the Market: An Analysis of Chromatography-Based Strategies.Frontiers in bioengineering and biotechnology · 2021Review
- Fractal dimension of antibody-PEG precipitate: Light microscopy for the reconstruction of 3D precipitate structures.Engineering in life sciences · 2020Article
- Optimized polymer-based glucose release in microtiter plates for small-scaleJournal of biological engineering · 2020Article
- Optimization of integrated chromatography sequences for purification of biopharmaceuticals.Biotechnology progress · 2019Article
- Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation.Bioprocess and biosystems engineering · 2019Article
- Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development.Frontiers in bioengineering and biotechnology · 2019Review
- Editorial: Bioprocess Development in the era of digitalization.Engineering in life sciences · 2017Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biopharmaceutical industry is at a turning point moving toward a more customized and patient-oriented medicine (precision medicine). Straightforward routines such as the antibody platform process are extended to production processes for a new portfolio of molecules. As a consequence, individual and tailored productions require generic approaches for a fast and dedicated purification process development. In this article, different effective strategies in biopharmaceutical purification process development are reviewed that can analogously be used for the new generation of antibodies. Conventional approaches based on heuristics and high-throughput process development are discussed and compared to modern technologies such as multivariate calibration and mechanistic modeling tools. Such approaches constitute a good foundation for fast and effective process development for new products and processes, but their full potential becomes obvious in a correlated combination. Thus, different combinatorial approaches are presented, which might become future directions in the biopharmaceutical industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.