Evidence map›Paper›PMID 32624525›Full record

ArticleDental materials journal2020

Enhanced silver diamine fluoride therapy using the PILP method -A nanoindentation study.

Hamid Nurrohman, Stefan Habelitz, Kuniko Saeki, Alireza Sadr, Laurie B Gower, Vanessa Pazdernik, Junji Tagami, Sally J Marshall, Grayson W Marshall

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dental materials journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Hamid NurrohmanMissouri School of Dentistry and Oral Health, A.T. Still University.
Stefan HabelitzDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco.
Kuniko SaekiDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco.
Alireza SadrBiomimetics Biomaterials Biophotonics & Technology Laboratory, Department of Restorative Dentistry, University of Washington School of Dentistry.
Laurie B GowerMaterials Science and Engineering Department, University of Florida.
Vanessa PazdernikDepartment of Research Support, A. T. Still University.
Junji TagamiDepartment of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
Sally J MarshallDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco.
Grayson W MarshallDepartment of Preventive and Restorative Dental Sciences, University of California San Francisco.
University of California, San Francisco · USA.T. Still University · USTokyo Medical and Dental University · JPUniversity of Florida · USUniversity of Washington · US

Funding

DENTIN STRUCTURE, DEMINERALIZATION AND REMINERALIZATIONR01DE016849 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOWER, LAURIE B, HABELITZ, STEFAN FRIEDRICH · 2006 to 2016
$5.1M
Remineralization carious lesions in dentin using the PILP-approachR21DE028421 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HABELITZ, STEFAN FRIEDRICH · 2019 to 2020
$443k
NIDCR NIH HHS R01 DE016849NIDCR NIH HHS R21 DE028421
6 · The paper itself

Abstract

The aim of this study was to evaluate the feasibility of applying the polymer-induced liquid-precursor (PILP) method to enhance silver diamine fluoride (SDF) therapy. One hundred forty micrometer deep artificial caries lesions were treated with (A) 38% SDF solution and (B) 38% SDF containing poly-L-aspartic acid (pASP). Changes in the nanomechanical profile across the lesion were evaluated. Hydrated artificial lesions had a low reduced elastic modulus (0.3 GPa) and nanohardness (0.02 GPa) region extending about 100 μm into the lesion, with a gradual linear increase to about 168 μm where the values plateaued to around 18 GPa/1.0 GPa. Topical application of SDF resulted in significantly recovered properties (p<0.001). SDF containing pASP resulted in greater nanomechanical properties compared to SDF alone, showing similar sloped regions up to 96 μm, then SDF alone dropped while SDF containing pASP continued at a modest slope until reaching normal at 144 μm. This nanoindentation study shows enhanced SDF therapy using the PILP method.

Indexed as

Dental CariesDentinCariostatic AgentsFluorides, TopicalHumansQuaternary Ammonium CompoundsSilver CompoundsCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideArtificial caries dentin lesionCaries arrestNanomechanical recoveryPolymer-induced liquid-precursorSilver diamine fluoride

Identifiers

PMID32624525
PMCPMC8376189
OpenAlexW3038136459

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.