Evidence map›Paper›PMID 32624483›Full record

ArticleBMJ case reports2020

Successful treatment of resistant HCV in a patient with Child-Pugh B cirrhosis using sofosbuvir and glecaprevir/pibrentasvir.

Munim Islam, Sarah Nicholas, Rhys Oakley, Brendan Healy

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Munim IslamMicrobiology/Infectious Diseases, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK munim.islam@nhs.net.
Sarah NicholasInfectious Diseases, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK.
Rhys OakleyPharmacy, University Hospital of Wales Healthcare NHS Trust, Cardiff, UK.
Brendan HealyMicrobiology/Infectious Diseases, Public Health Wales NHS Trust, Cardiff, UK.
University Hospital of Wales · GBPublic Health Wales · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatments for hepatitis C are now well tolerated with very high rates of sustained virological response and almost all patients have a suitable and effective treatment option. However, treatment options remain limited for a minority of patients and are limited for patients with Child-Pugh B or C cirrhosis due to the risk of decompensation with protease inhibitors. We present a case of successful treatment with glecaprevir/pibrentasvir (Maviret) and sofosbuvir in a patient with Child-Pugh B cirrhosis and resistant virus who had failed three previous attempts of treatment including two courses of direct acting antiviral agents and in whom liver transplantation was deemed unsuitable. We propose that the balance of risks favours a trial of treatment with protease inhibitors in some circumstances in patients with Child-Pugh B cirrhosis where no other suitable alternatives including treatment post liver transplantation are available/appropriate.

Indexed as

Antiviral AgentsBenzimidazolesDrug Administration ScheduleDrug CombinationsDrug Therapy, CombinationHepatitis C, ChronicHumansLiver CirrhosisMaleMiddle AgedPyrrolidinesQuinoxalinesSofosbuvirSulfonamidesAntiviral AgentsBenzimidazolesDrug Combinationsglecaprevir and pibrentasvirPyrrolidinesQuinoxalinesSofosbuvirSulfonamidesdrugs: infectious diseaseshepatitis and other GI infectionshepatitis Cinfections

Identifiers

PMID32624483
PMCPMC7337621
OpenAlexW3039137985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.