Evidence map›Paper›PMID 32624357›Full record

ReviewPaediatric respiratory reviews2020

Advances in the diagnosis of pulmonary tuberculosis in children.

Mark P Nicol, Heather J Zar

Open access · greenAbstract readReview
In one paragraph

Review in Paediatric respiratory reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Clinical characteristics and risk factors of severe pulmonary tuberculosis in children in Yunnan, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
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  16. Trends and challenges of multi-drug resistance in childhood tuberculosis.Frontiers in cellular and infection microbiology · 2023
    Review
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mark P NicolDivision of Infection and Immunity, School of Biomedical Sciences, University of Western Australia, Perth, Australia. Electronic address: Mark.Nicol@uwa.edu.au.
Heather J ZarDepartment of Paediatrics and Child Health, and SA-MRC Unit on Child & Adolescent Health, University of Cape Town and Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
The University of Western Australia · AUUniversity of Cape Town · ZA

Funding

The nasopharyngeal microbiota of African children and lower respiratory tract infectionU54HG009824 · NHGRI · UNIVERSITY OF CAPE TOWN · PI NICOL, MARK PATRICK · 2017 to 2021
$2.9M
Diagnosis of Tuberculosis in HIV-infected children & development of microbiologicR01HD058971 · NICHD · UNIVERSITY OF CAPE TOWN · PI ZAR, HEATHER JOY · 2008 to 2012
$2.2M
NHGRI NIH HHS U54 HG009824NICHD NIH HHS R01 HD058971
6 · The paper itself

Abstract

Major challenges still exist in the accurate diagnosis of tuberculosis in children. Algorithms based on clinical and radiological features remain in widespread use despite poor performance. Newer molecular diagnostics allow for rapid identification of TB and detection of drug-resistance in a subset of children, but lack sensitivity. Molecular testing of multiple specimens, including non-traditional specimen types, such as nasopharyngeal aspirates and stool and urine, may improve sensitivity, but the optimal combination of specimens requires further research. Novel tests under development or evaluation include a urine lipoarabinomannan test with improved sensitivity and a range of biomarkers measured from stimulated or unstimulated peripheral blood.

Indexed as

ChildCulture TechniquesFecesHumansInterferon-gamma Release TestsLipopolysaccharidesMicroscopyMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesSputumTuberculosis, Multidrug-ResistantTuberculosis, PulmonarylipoarabinomannanLipopolysaccharidesBiomarkerChildrenDiagnosisLAMTuberculosisXpert

Identifiers

PMID32624357
PMCPMC7686111
OpenAlexW3028671065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.