ArticleFertility and sterility2020
Contributions to prematurity of maternal health conditions, subfertility, and assisted reproductive technology.
Article in Fertility and sterility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Obstetric outcomes after IVF/ICSI treatment in women with endometriosis and/or adenomyosis diagnosed by ultrasonography: a prospective cohort study.Human reproduction (Oxford, England) · 2026Observational
- Fertility treatment and risk of cerebral palsy: has the association changed in Australia?Human reproduction (Oxford, England) · 2026Article
- Preterm birth in assisted reproduction: the mediating role of hypertensive disorders in pregnancy.Human reproduction (Oxford, England) · 2025Article
- Comparing the occurrence rate of gestational hypertension during pregnancy with frozen embryo transfer and natural pregnancy.Journal of family medicine and primary care · 2023Article
- Regulated necrosis role in inflammation and repair in acute kidney injury.Frontiers in immunology · 2023Review
- Article
- Assisted reproductive technology treatment increases obstetric and neonatal risks over that of the underlying infertility diagnosis.Fertility and sterility · 2022Article
- The health of in vitro fertilization-conceived children: The Blind Men and the Elephant.Fertility and sterility · 2021Article
- Influence of Placental Abnormalities and Pregnancy-Induced Hypertension in Prematurity Associated with Various Assisted Reproductive Technology Techniques.Journal of clinical medicine · 2021Article
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo determine the maternal demographic, health, and fertility variables underlying prematurity.
designRetrospective: Society for Assisted Reproductive Technology Clinic Outcome Reporting System data linked to Massachusetts birth certificates and hospital stays.
settingNot applicable. PATIENTS: We included 166,963 privately insured, singleton, first births to women ≥18 years of age between 2004 and 2013. Deliveries were as follows: assisted reproductive technology (ART) when linked to Society for Assisted Reproductive Technology Clinic Outcome Reporting System, medically assisted reproduction (MAR) when fertility treatment was indicated on the birth certificate, unassisted subfertile (USF) when there were indications of subfertility but no treatment, and fertile if none of the above.
interventionNone.
main outcome measuresLate preterm birth (LPTB; 34-36 weeks) and early preterm birth (EPTB; <34 weeks) were compared with term deliveries (≥37 weeks). Covariates that statistically significantly influenced prematurity in binary analysis were modeled by using multinomial logistic regression. Backward elimination and mediation analysis were used to determine the influence of single parameters on outcomes of others.
resultsLPTB was increased in the USF (adjusted odds ratio [AOR] 1.32, 95% confidence interval [CI] 1.06-1.65) and ART (AOR 1.42, 95% CI 1.30-1.56) but not MAR (AOR 1.16, 95% CI 0.98-1.37). ETPB was increased in all (USF: AOR 1.67, 95% CI 1.21-2.31; MAR: AOR 1.67, 95% CI 1.31-2.12; ART: AOR 1.40, 95% CI 1.21-1.61). The strongest effectors of prematurity were placental problems (LPTB: AOR 4.02; EPTB: AOR 10.28), pregnancy hypertension (LPTB: AOR 2.14; EPTB: AOR 2.88), and chronic hypertension (LPTB: AOR 1.85; EPTB: AOR 2.79). Mediation analysis demonstrated a statistically significant indirect effect of placental problems for ART and subfertility.
conclusionThe greatest effectors of prematurity were placental problems and hypertensive disorders. ART and, to a lesser extent, subfertility were both associated with preterm birth directly and indirectly mediated by placenta problems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.