ArticlePsychological medicine2022
Familial risk for depressive and anxiety disorders: associations with genetic, clinical, and psychosocial vulnerabilities.
Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Health effects associated with exposure of children to physical violence, psychological violence and neglect: a Burden of Proof study.Nature human behaviour · 2025Pooled it
- Association between household environment and the risk of depression and anxiety among women in Bangladesh: analysis of the Bangladesh Demographic and Health Survey (2022).The Lancet regional health. Southeast Asia · 2026Article
- Mental Health Disorders and Coping Strategies Among Palestinian Refugees in Egypt During the 2023 War on Gaza: A Cross-Sectional Study.The International journal of social psychiatry · 2026Article
- Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.Social psychiatry and psychiatric epidemiology · 2026Article
- Intergenerational associations of depression and anxiety among adult mother-daughter dyads in China.European psychiatry : the journal of the Association of European Psychiatrists · 2026Article
- Mental health among pharmacy students, assessing predictors of clinically significant anxiety and depression: a cross-sectional study from Jordan.BMC medical education · 2026Article
- Polygenic scores for psychiatric traits mediate the impact of multigenerational history for depression on offspring psychopathology.Molecular psychiatry · 2026Article
- Prevalence and risk factors of depression, anxiety, and stress among secondary school students in Abha city, Saudi Arabia.Frontiers in psychiatry · 2026Article
- Transdiagnostic prevention in youth mental health, Part II: interventions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Association of psychiatric comorbidities with chronic urticaria: a nested case-control study in the All of Us research program.JEADV clinical practice · 2025Article
- Effectiveness of nurses' training about mechanical ventilation weaning on neonatal outcomes.BMC nursing · 2025Article
- Investigating Lifestyle Risk and Protective Factors for Depression in Young Adults: Insights From a Large-Scale Cross-Sectional Study.American journal of lifestyle medicine · 2025Article
- Influence of tobacco smoking and alcohol drinking on anxiety in sample of 30 836 individuals in Taiwan Biobank.BJPsych open · 2025Article
- Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2025Article
- Article
- The interplay of family history of depression and early trauma: associations with lifetime and current depression in the German national cohort (NAKO).Frontiers in epidemiology · 2023Article
- Familial load of psychiatric disorders and overall functioning in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives.International journal of bipolar disorders · 2022Article
- Impairments of Social Interaction in Depressive Disorder.Psychiatry investigation · 2022Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn research and clinical practice, familial risk for depression and anxiety is often constructed as a simple Yes/No dichotomous family history (FH) indicator. However, this measure may not fully capture the liability to these conditions. This study investigated whether a continuous familial loading score (FLS), incorporating family- and disorder-specific characteristics (e.g. family size, prevalence of depression/anxiety), (i) is associated with a polygenic risk score (PRS) for major depression and with clinical/psychosocial vulnerabilities and (ii) still captures variation in clinical/psychosocial vulnerabilities after information on FH has been taken into account.
methodsData came from 1425 participants with lifetime depression and/or anxiety from the Netherlands Study of Depression and Anxiety. The Family Tree Inventory was used to determine FLS/FH indicators for depression and/or anxiety.
resultsPersons with higher FLS had higher PRS for major depression, more severe depression and anxiety symptoms, higher disease burden, younger age of onset, and more neuroticism, rumination, and childhood trauma. Among these variables, FH was not associated with PRS, severity of symptoms, and neuroticism. After regression out the effect of FH from the FLS, the resulting residualized measure of FLS was still associated with severity of symptoms of depression and anxiety, rumination, and childhood trauma.
conclusionsFamilial risk for depression and anxiety deserves clinical attention due to its associated genetic vulnerability and more unfavorable disease profile, and seems to be better captured by a continuous score that incorporates family- and disorder-specific characteristics than by a dichotomous FH measure.
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