Evidence map›Paper›PMID 32623977›Full record

Trial reportStroke2020

Sex Differences in Blood Pressure-Lowering Therapy and Outcomes Following Intracerebral Hemorrhage: Results From ATACH-2.

Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yuko Y Palesch, Valerie L Durkalski-Mauldin, Adnan I Qureshi, Sohei Yoshimura, Shuhei Okazaki, Kaori Miwa, Yasushi Okada and 5 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01176565 (Antihypertensive Treatment of Acute Cerebral Hemorrhage), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01176565 phase3terminatednot on this map

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-II: A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage

TypeinterventionalSponsorUniversity of MinnesotaRan2011 to 2016Enrolled1,000ConditionsIntracerebral HemorrhageArmsIntravenous nicardipine hydrochloride
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Mayumi Fukuda-DoiDepartment of Cerebrovascular Medicine (M.F.-D., M.K., S.Y., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita, Japan.
Haruko YamamotoCenter for Advancing Clinical and Translational Sciences (M.F.-D., H.Y.), National Cerebral and Cardiovascular Center, Suita, Japan.
Masatoshi KogaDepartment of Cerebrovascular Medicine (M.F.-D., M.K., S.Y., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita, Japan.
Yuko Y PaleschDepartment of Public Health Sciences, Medical University of South Carolina, Charleston (Y.Y.P., V.L.D.-M.).
Valerie L Durkalski-MauldinDepartment of Public Health Sciences, Medical University of South Carolina, Charleston (Y.Y.P., V.L.D.-M.).
Adnan I QureshiZeenat Qureshi Stroke Institute, St. Cloud, MN (A.I.Q.).
Sohei YoshimuraDepartment of Cerebrovascular Medicine (M.F.-D., M.K., S.Y., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita, Japan.
Shuhei OkazakiDepartment of Neurology (S. Okazaki), National Cerebral and Cardiovascular Center, Suita, Japan.
Kaori MiwaDepartment of Cerebrovascular Medicine (M.F.-D., M.K., S.Y., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita, Japan.
Yasushi OkadaDepartment of Cerebrovascular Medicine and Neurology, National Hospital Organization Kyushu Medical Center Clinical Research Institute, Fukuoka, Japan (Y.O.).
Toshihiro UedaDepartment of Strokology, Stroke Center, St. Marianna University Toyoko Hospital, Kawasaki, Japan (T.U.).
Satoshi OkudaDepartment of Neurology, National Hospital Organization Nagoya Medical Center, Japan (S. Okuda).
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan (M.F.-D., J.N., N.S., K.T.).
Norihiro SuzukiDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan (M.F.-D., J.N., N.S., K.T.).
Kazunori ToyodaDepartment of Cerebrovascular Medicine (M.F.-D., M.K., S.Y., K.M., K.T.), National Cerebral and Cardiovascular Center, Suita, Japan.
Keio University · JPNational Cerebral and Cardiovascular Center · JPMedical University of South Carolina · USCentraCare Health System · USNagoya Medical Center · JPNational Kyushu Medical Center · JPOkazaki National Research Institutes · JPSt. Marianna University School of Medicine · JP

Funding

Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH-II)U01NS062091 · NINDS · UNIVERSITY OF MINNESOTA · PI QURESHI, ADNAN IQBAL · 2010 to 2014
$18.1M
Neurological Emergencies Treatment Trials Network Statistical and Data ManagementU01NS059041 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DURKALSKI, VALERIE L, PALESCH, YUKO Y · 2006 to 2015
$9.1M
Statistical and Data Coordinating Center for the ATACH - 2U01NS061861 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PALESCH, YUKO Y · 2010 to 2014
$2.2M
NINDS NIH HHS U01 NS059041NINDS NIH HHS U01 NS061861NINDS NIH HHS U01 NS062091
6 · The paper itself

Abstract

background and purposeEvidence regarding sex differences in clinical outcomes and treatment effect following intracerebral hemorrhage is limited. Using the ATACH-2 trial (Antihypertensive Treatment in Intracerebral Hemorrhage-2) data, we explored whether sex disparities exist in outcomes and response to intensive blood pressure (BP)-lowering therapy.

methodsEligible intracerebral hemorrhage subjects were randomly assigned to intensive (target systolic BP, 110-139 mm Hg) or standard (140-179 mm Hg) BP-lowering therapy within 4.5 hours after onset. Relative risk of death or disability corresponding to the modified Rankin Scale score of 4 to 6 was calculated, and interaction between sex and treatment was explored.

resultsIn total, 380 women and 620 men were included. Women were older, more prescribed antihypertensive drugs before onset, and had more lobar intracerebral hemorrhage than men. Hematoma expansion was observed less in women. After multivariable adjustment, the relative risk of death or disability in women was 1.19 (95% CI, 1.02-1.37,

conclusionsWomen had a higher risk of death or disability following intracerebral hemorrhage. The benefit of intensive BP-lowering therapy in women is inconclusive, consistent with the overall results of ATACH-2. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01176565.

Indexed as

Sex CharacteristicsAgedAntihypertensive AgentsBlood PressureCerebral HemorrhageFemaleHumansHypertensionInternationalityMaleMiddle AgedTreatment OutcomeAntihypertensive Agentsblood pressurecerebral hemorrhageclinical trialhematomasex

Identifiers

PMID32623977
PMCPMC9371624
OpenAlexW3039879965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.