Evidence map›Paper›PMID 32623628›Full record

Trial reportEuropean journal of pediatrics2021

Effect of delayed cord clamping on stem cell transfusion and hematological parameters in preterm infants with placental insufficiency: a pilot randomized trial.

Mohammed Yunis, Islam Nour, Ahmed Gibreel, Mohamad Darwish, Mohamed Sarhan, Basma Shouman, Nehad Nasef

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03731546 (Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency), which is not on this map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03731546 nacompletednot on this map

Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency

TypeinterventionalSponsorMansoura University Children HospitalRan2017 to 2019Enrolled90ConditionsPreterm Infant, Placental Insufficiency, Placental TransfusionArmsDelayed cord clamping
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mohammed YunisNeonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt.
Islam NourNeonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt.
Ahmed GibreelDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.
Mohamad DarwishDepartment of Clinical Pathology, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.
Mohamed SarhanDepartment of Pediatrics, Faculty of Medicine, University of Mansoura, Mansoura, Egypt.
Basma ShoumanNeonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt.
Nehad NasefNeonatal Intensive Care Unit, Department of Pediatrics, Mansoura University Children's Hospital, Gomhoria Street, Mansoura, 35516, Egypt. nehad_nasef@mans.edu.eg.ORCID http://orcid.org/0000-0001-7650-123X
Mansoura University · EGChildren's Hospital Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The feasibility of delayed cord clamping (DCC) in preterm infants with placental insufficiency (PI) is questionable. We aimed to study the effect of DCC on stem cell transfusion, hematological parameters, and clinical outcomes in preterm infants born to mothers with PI. Preterm infants, < 34 weeks' gestation, born to mothers with PI were randomized based on the timing of umbilical cord clamping into delayed clamping for 60 s (DCC group) or immediate cord clamping (ICC group) groups at time of birth. CD34 percentage as a marker of stem cell transfusion, early and late-onset anemia, hypothermia, hypotension, polycythemia, hyperbilirubinemia, duration of oxygen therapy, bronchopulmonary dysplasia, intra-ventricular hemorrhage, necrotizing enterocolitis, sepsis, mortality, and length of hospital stay were compared between studied groups. We found that peripheral blood CD34 percentage was significantly higher in DCC compared with that in the ICC group (median (IQR) of 0.5 (0.40-0.7) versus 0.35 (0.20-0.5), p = 0.004). Infants in the DCC group had significantly lower episodes of anemia of prematurity at 2 months, red blood cell transfusion, and shorter duration of oxygen therapy compared with those in the ICC group.Conclusion: In conclusion, DCC compared with ICC increased stem cell transfusion and decreased early- and late-onset anemia in preterm infants with placental insufficiency.Trial registration: NCT03731546 www.clinicaltrials.gov What is Known: • Delayed cord clamping has been recommended by the American Academy of Pediatrics as a standard of care practice during delivery of preterm infants. • The feasibility of DCC in preterm infants with placental insufficiency (PI) is uncertain. What is New: • This randomized controlled trial demonstrated that DCC in the delivery room care of preterm infants born to mothers with placental insufficiency increased stem cell transfusion and decreased early- and late-onset anemia.

Indexed as

Infant, PrematurePlacental InsufficiencyChildConstrictionDelivery, ObstetricFemaleHumansInfantInfant, NewbornPilot ProjectsPlacentaPregnancyStem CellsUmbilical CordAnemia neonatorumPlacental insufficiencyPreterm infantStem cellUmbilical cord

Identifiers

PMID32623628
OpenAlexW3039048767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.