ArticleAnnals of surgical oncology2020
Intraoperative Pathologic Margin Analysis and Re-Excision to Minimize Reoperation for Patients Undergoing Breast-Conserving Surgery.
Article in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Staged Reconstruction Is Not Necessary Following Oncologic Resection of Superficial Myxofibrosarcoma.Cancers · 2025Article
- Real-World Application of Alliance ACOSOG Z11102: How Many Patients Can be Spared Mastectomy?Annals of surgical oncology · 2025Article
- Article
- Exploratory multi-cohort, multi-reader study on the clinical utility of a deep learning model for transforming cryosectioned to formalin-fixed, paraffin-embedded (FFPE) images in breast lesion diagnosis.Breast cancer research : BCR · 2025Article
- Touching the tumor boundary: a pilot study on ultrasound-based virtual fixtures for breast-conserving surgery.International journal of computer assisted radiology and surgery · 2025Article
- Confocal Laser Microscopy for Intraoperative Margin Assessment in Breast-Conserving Surgery: A New Procedure in the Pathology Laboratory Workflow.The American journal of surgical pathology · 2025Article
- Impact of cavity shave margins in patients with ductal carcinomaFrontiers in oncology · 2024Article
- Guidance in breast-conserving surgery: tumour localization versus identification.The British journal of surgery · 2023Article
- Breast-Conserving Surgery Margin Guidance Using Micro-Computed Tomography: Challenges When Imaging Radiodense Resection Specimens.Annals of surgical oncology · 2023Article
- Pathologic evaluation of lumpectomy resection margins for invasive breast cancer: a single institution's experience.International journal of clinical and experimental pathology · 2023Article
- Improving ductal carcinoma in situ classification by convolutional neural network with exponential linear unit and rank-based weighted pooling.Complex & intelligent systems · 2021Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
backgroundReoperation rates following breast-conserving surgery (BCS) range from 10 to 40%, with marked surgeon and institutional variation.
objectiveThe aim of this study was to identify factors associated with intraoperative margin re-excision, evaluate for any differences in local recurrence based on margin re-excision and determine reoperation rates with use of intraoperative margin analysis. PATIENTS AND
methodsWe analyzed consecutive patients with ductal carcinoma in situ (DCIS) or invasive breast cancer who underwent BCS at our institution between 1 January 2005 and 31 December 2016. Routine intraoperative frozen section margin analysis was performed and positive or close margins were re-excised intraoperatively. Univariate analysis was used to compare margin status and the Kaplan-Meier method was used to compare recurrence. Multivariable logistic regression was utilized to analyze factors associated with re-excision.
resultsWe identified 3201 patients who underwent BCS-688 for DCIS and 2513 for invasive carcinoma. Overall, 1513 (60.2%) patients with invasive cancer and 434 (63.1%) patients with DCIS had close or positive margins that underwent intraoperative re-excision. Margin re-excision was associated with larger tumor size in both groups. The permanent pathology positive margin rate among all patients was 1.2%, and the 30-day reoperation rate for positive margins was 1.1%. Five-year local recurrence rates were 0.6% and 1.2% for patients with DCIS and invasive cancer, respectively. There was no difference in recurrence between patients with and without intraoperative margin re-excision (p = 0.92).
conclusionBoth DCIS and invasive carcinoma had similar rates of intraoperative margin re-excision. Although intraoperative margin re-excision was common, the reoperation rate was extremely low and there was no difference in recurrence between those with or without intraoperative re-excision.
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