Evidence map›Paper›PMID 32623596›Full record

ArticleJournal of neurology2020

Cell-based assays for the detection of MOG antibodies: a comparative study.

Matteo Gastaldi, Silvia Scaranzin, Sven Jarius, Brigitte Wildeman, Elisabetta Zardini, Giulia Mallucci, Eleonora Rigoni, Elisa Vegezzi, Thomas Foiadelli, Salvatore Savasta and 13 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Beyond Positivity: Understanding and Interpreting MOG-IgG Testing in MOGAD.Journal of clinical neurology (Seoul, Korea) · 2026
    Review
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  16. Observational
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  20. Role of soluble biomarkers in treating multiple sclerosis and neuroinflammatory conditions.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 12 institutions in 5 countries.

Matteo GastaldiNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy. matteo.gastaldi@mondino.it.ORCID http://orcid.org/0000-0003-2288-2000
Silvia ScaranzinNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Sven JariusMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Otto Meyerhof Center, Heidelberg, Germany.
Brigitte WildemanMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Otto Meyerhof Center, Heidelberg, Germany.
Elisabetta ZardiniNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Giulia MallucciMultiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy.
Eleonora RigoniMultiple Sclerosis Centre, IRCCS Mondino Foundation, Pavia, Italy.
Elisa VegezziNeuro-Oncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia, Italy.
Thomas FoiadelliPediatric Clinic, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Salvatore SavastaPediatric Clinic, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Paola BanfiNeurology and Stroke Unit, Circolo Hospital/Macchi Foundation, University of Insubria, Varese, Italy.
Maurizio VersinoNeurology and Stroke Unit, Circolo Hospital/Macchi Foundation, University of Insubria, Varese, Italy.
Luana BenedettiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Giovanni NoviDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Margherita Maria MancardiUnit of Child Neuropsychiatry, Clinical and Surgical Neurosciences Department, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Thea GiacominiUnit of Child Neuropsychiatry, Clinical and Surgical Neurosciences Department, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Pietro AnnovazziMultiple Sclerosis Centre, ASST Valle Olona - Gallarate Hospital, Gallarate, Italy.
Damiano BaronciniMultiple Sclerosis Centre, ASST Valle Olona - Gallarate Hospital, Gallarate, Italy.
Diana FerraroDepartment of Biomedical, Metabolic and Neurosciences, University of Modena and Reggio Emilia, Modena, Italy.
Vito LampasonaSan Raffaele Diabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy.
Markus ReindlClinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Patrick WatersAutoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
Diego FranciottaNeuroimmunology Laboratory, IRCCS Mondino Foundation, Pavia, Italy.
Fondazione Istituto Neurologico Nazionale Casimiro Mondino · ITHeidelberg University · DEIstituto Giannina Gaslini · ITUniversity of Insubria · ITUniversity of Pavia · ITFoundation Center · USInnsbruck Medical University · ATOspedale Policlinico San Martino · ITUniversity of Genoa · ITUniversity of Modena and Reggio Emilia · ITUniversity of Oxford · GBVita-Salute San Raffaele University · IT

Funding

Ministero della Salute RC1812C
6 · The paper itself

Abstract

backgroundThe detection of antibodies to myelin oligodendrocyte glycoprotein (MOG) is fundamental for the identification of MOG antibody-associated disorders (MOGAD), and the differential diagnosis of acquired demyelinating syndromes of the CNS, among which multiple sclerosis (MS). We compared the diagnostic performance of four cell-based assays (CBAs) for their detection.

methodsConsecutive sera from 204 patients with 'possible MOGAD' (55), MS (112), and other neurological disorders (OND, 37) were tested for MOG-IgG with a live-CBA with anti-heavy-and-light chain secondary-antibody (LCBA-IgG

conclusionsLCBA-IgG

Indexed as

AutoantibodiesMultiple SclerosisHumansImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinSyndromeAutoantibodiesImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinAutoantibodiesCell-based assayDemyelinating disordersMultiple sclerosisMyelin oligodendrocyte glycoproteinMyelitisOptic neuritisStandardization

Identifiers

PMID32623596
OpenAlexW3038260603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.