ArticleNeurobiology of aging2020
Frontostriatal white matter connectivity: age differences and associations with cognition and BOLD modulation.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- The decline in cognitive function with age and its changes over time in cognitively normal older adults.European geriatric medicine · 2026Article
- Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.Science advances · 2025Article
- White Matter Differences in Early-Stage Alcohol Use Disorder: Diffusion Tensor and Neurite Orientation Dispersion and Density Measures of Structural Integrity.Addiction biology · 2025Article
- Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Towards a neurodevelopmental cognitive perspective of temporal processing.Communications biology · 2024Review
- Prediction in the Aging Brain: Merging Cognitive, Neurological, and Evolutionary Perspectives.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Age-related degradation of optic radiation white matter predicts visual, but not verbal executive functions.Aperture neuro · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Despite the importance of cortico-striatal circuits to cognition, investigation of age effects on the structural circuitry connecting these regions is limited. The current study examined age effects on frontostriatal white matter connectivity, and identified associations with both executive function performance and dynamic modulation of blood-oxygen-level-dependent (BOLD) activation to task difficulty in a lifespan sample of 169 healthy humans aged 20-94 years. Greater frontostriatal diffusivity was associated with poorer executive function and this negative association strengthened with increasing age. Whole-brain functional magnetic resonance imaging (fMRI) analyses additionally indicated an association between frontostriatal mean diffusivity and BOLD modulation to difficulty selectively in the striatum across 2 independent fMRI tasks. This association was moderated by age, such that younger- and middle-aged individuals showed reduced dynamic range of difficulty modulation as a function of increasing frontostriatal diffusivity. Together these results demonstrate the importance of age-related degradation of frontostriatal circuitry on executive functioning across the lifespan, and highlight the need to capture brain changes occurring in early-to middle-adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.