ArticleDrug and alcohol dependence2020
The association between regular cocaine use, with and without tobacco co-use, and adverse cardiovascular and respiratory outcomes.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Effects of substance use disorder on oxidative and antioxidative stress markers: A systematic review and meta-analysis.Addiction biology · 2023Pooled it
- Attitudes toward tobacco-free and cannabis-free policies among residents in permanent supportive housing who use tobacco, cannabis, and other substances.Addictive behaviors reports · 2026Article
- Determinants of the willingness to reduce or quit cocaine use among nightlife attendees.Archives of public health = Archives belges de sante publique · 2025Article
- Understanding clustered behavioral risk factors among adults in the United States: A gender-specific analysis of alcohol and other substance use and obesity.Alcohol, clinical & experimental research · 2025Article
- Distinct cardiac troponin alterations in patients with cocaine and alcohol use disorders during abstinence for cardiovascular risk assessment.Scientific reports · 2025Observational
- Article
- Cardiovascular Risks of Simultaneous Use of Alcohol and Cocaine-A Systematic Review.Journal of clinical medicine · 2024Review
- Anomalous origin of the left circumflex coronary artery: is surgery required? A case report.European heart journal. Case reports · 2024Article
- Risky drinking and other drug use in adults with chronic conditions in the United States: differential associations by race/ethnicity.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Article
- The association between dual use of electronic nicotine products and illicit drugs with adverse cardiovascular and respiratory outcomes in a longitudinal analysis using the Population Assessment of Tobacco and Health (PATH) survey.Drug and alcohol dependence reports · 2023Article
- Article
- Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundUnderstanding the potential impact of cocaine use on health is increasingly important as cocaine use rises in the U.S.
objectivesThis study evaluated the associations of regular cocaine use, with and without tobacco co-use, with cardiovascular and respiratory outcomes.
methodsAnalysis of a limited dataset obtained through IBM Watson Health Explorys, a platform integrating electronic health record data. Matched controls were defined for: 1) cocaine-using patients (n = 8244; 44 % female); and subgroups of cocaine-using patients: 2) with an encounter diagnosis for tobacco use disorder (TUD; n = 4706); and 3) without a TUD diagnosis (non-TUD; n = 3538). Patients had at least one documented medical evaluation in the MetroHealth System (Cleveland, Ohio). Cocaine-using patients had an encounter diagnosis of cocaine abuse/dependence and/or ≥2 cocaine-positive drug screens. Control patients, with no documented cocaine-use, were matched to the cocaine-using patients on demographics, residential zip code median income, body mass index, and, for the total sample, TUD-status. Outcomes were encounter diagnosis (yes/no) of cerebrovascular accident, heart arrhythmia, myocardial infarction, subarachnoid hemorrhage, asthma, chronic obstructive pulmonary disease (COPD), pneumonia, and all-cause mortality.
resultsTUD-patients had the greatest prevalence of cardiovascular and respiratory disease, regardless of cocaine-use indication. In the total sample, TUD, and non-TUD subgroups, regular cocaine use was significantly associated with greater risk for cerebrovascular accident, arrhythmia, myocardial infarction, asthma, COPD, pneumonia and mortality.
conclusionsCocaine use is associated with significantly greater risk of adverse cardiovascular and respiratory diagnoses and all-cause mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.