ArticleNeuroImage. Clinical2020
Emotion self-regulation training in major depressive disorder using simultaneous real-time fMRI and EEG neurofeedback.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 5 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Self-navigating the "Island of Reil": a systematic review of real-time fMRI neurofeedback training of insula activity.Translational psychiatry · 2025Pooled it
- Effects of neurofeedback on major depressive disorder: a systematic review.Einstein (Sao Paulo, Brazil) · 2023Pooled it
- Simultaneous real-time EEG-fMRI neurofeedback: A systematic review.Frontiers in human neuroscience · 2023Pooled it
- The efficacy of real-time functional magnetic resonance imaging neurofeedback for psychiatric illness: A meta-analysis of brain and behavioral outcomes.Neuroscience and biobehavioral reviews · 2021Pooled it
- A systematic review of fMRI neurofeedback reporting and effects in clinical populations.NeuroImage. Clinical · 2020Pooled it
- Review
- Smart Devices and Multimodal Systems for Mental Health Monitoring: From Theory to Application.Bioengineering (Basel, Switzerland) · 2026Review
- Neurofeedback in Major Depression.Advances in experimental medicine and biology · 2026Review
- Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- From anxiety to depression: A longitudinal investigation into the role of anhedonia.Journal of affective disorders · 2025Article
- Advances in Neuroimaging and Deep Learning for Emotion Detection: A Systematic Review of Cognitive Neuroscience and Algorithmic Innovations.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluation of Theta EEG Neurofeedback Procedure for Cognitive Training Using Simultaneous fMRI in Counterbalanced Active-Sham Study Design.Human brain mapping · 2025Article
- Spiking neural networks for EEG signal analysis using wavelet transform.Frontiers in neuroscience · 2025Article
- Electroencephalography Neurofeedback Training with Focus on the State of Attention: An Investigation Using Source Localization and Effective Connectivity.Sensors (Basel, Switzerland) · 2024Article
- Multimodal and hemispheric graph-theoretical brain network predictors of learning efficacy for frontal alpha asymmetry neurofeedback.Cognitive neurodynamics · 2024Article
- Ventromedial prefrontal cortex activation and neurofeedback modulation during episodic future thinking for individuals with suicidal thoughts and behaviors.Behaviour research and therapy · 2024Article
- Validation of real-time fMRI neurofeedback procedure for cognitive training using counterbalanced active-sham study design.NeuroImage · 2024Article
- Research on intervention strategies for fire rescue personnel's competency frustration: EEG experimental validation.Frontiers in psychology · 2024Article
- No evidence from a negative mood induction fMRI task for frontal functional asymmetry as a suitable neurofeedback target.Scientific reports · 2023Article
- Real-time fMRI neurofeedback compared to cognitive behavioral therapy in a pilot study for the treatment of mild and moderate depression.European archives of psychiatry and clinical neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Simultaneous real-time fMRI and EEG neurofeedback (rtfMRI-EEG-nf) is an emerging neuromodulation approach, that enables simultaneous volitional regulation of both hemodynamic (BOLD fMRI) and electrophysiological (EEG) brain activities. Here we report the first application of rtfMRI-EEG-nf for emotion self-regulation training in patients with major depressive disorder (MDD). In this proof-of-concept study, MDD patients in the experimental group (n = 16) used rtfMRI-EEG-nf during a happy emotion induction task to simultaneously upregulate two fMRI and two EEG activity measures relevant to MDD. The target measures included BOLD activities of the left amygdala (LA) and left rostral anterior cingulate cortex (rACC), and frontal EEG asymmetries in the alpha band (FAA, [7.5-12.5] Hz) and high-beta band (FBA, [21-30] Hz). MDD patients in the control group (n = 8) were provided with sham feedback signals. An advanced procedure for improved real-time EEG-fMRI artifact correction was implemented. The experimental group participants demonstrated significant upregulation of the LA BOLD activity, FAA, and FBA during the rtfMRI-EEG-nf task, as well as significant enhancement in fMRI connectivity between the LA and left rACC. Average individual FAA changes during the rtfMRI-EEG-nf task positively correlated with depression and anhedonia severities, and negatively correlated with after-vs-before changes in depressed mood ratings. Temporal correlations between the FAA and FBA time courses and the LA BOLD activity were significantly enhanced during the rtfMRI-EEG-nf task. The experimental group participants reported significant mood improvements after the training. Our results suggest that the rtfMRI-EEG-nf may have potential for treatment of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.