Evidence map›Paper›PMID 32623139›Full record

ArticleNeuroImage. Clinical2020

Characterization of serial hyperpolarized

Adam W Autry, Jeremy W Gordon, Hsin-Yu Chen, Marisa LaFontaine, Robert Bok, Mark Van Criekinge, James B Slater, Lucas Carvajal, Javier E Villanueva-Meyer, Susan M Chang and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03739411 (Pilot Study of Safety and Feasibility of Acquiring Hyperpolarized Imaging in Patients With Gliomas), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03739411 phase1recruitingnot on this map

Pilot Study of Safety and Feasibility of Acquiring Hyperpolarized Imaging in Patients With Gliomas

TypeinterventionalSponsorSusan ChangRan2015 to 2028Enrolled140ConditionsGliomaArmsHyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Imaging, Radiation Therapy, Chemotherapy
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  6. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  12. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  13. Current methods for hyperpolarized [1-Magnetic resonance in medicine · 2024
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Hyperpolarized [2-NeuroImage · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Adam W AutryDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Marisa LaFontaineDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Mark Van CriekingeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Susan M ChangDepartment of Neurological Surgery, University of California San Francisco, San Francisco, USA.
Jennifer L ClarkeDepartment of Neurological Surgery, University of California San Francisco, San Francisco, USA.
Janine M LupoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Duan XuDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, USA.
Yan LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA. Electronic address: yan.li@ucsf.edu.
University of California System · USUniversity of California, San Francisco · USNeurological Surgery · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Project 4: Multi-modality Metabolic Imaging for Monitoring Molecular Sub-types of GliomaP01CA118816 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Pavithra Viswanath · 2007 to 2026
$44.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
MR Metabolic Markers for Evaluation of Patients with Recurrent GliomaR01CA127612 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LI, YAN · 2008 to 2017
$3.8M
NCI NIH HHS P01 CA118816NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA127612NCI NIH HHS T32 CA151022NIBIB NIH HHS P41 EB013598
6 · The paper itself

Abstract

backgroundHyperpolarized carbon-13 (HP-

methodsSerial dynamic HP [1-

resultsWhen excluding scans following anti-angiogenic therapy, patient values of k

conclusionSerial measures of HP [1-

Indexed as

Contrast MediaGliomaGadoliniumHumansMagnetic Resonance ImagingProspective StudiesPyruvic AcidContrast MediaGadoliniumPyruvic AcidBevacizumabCarbon-13GliomaHyperpolarizedKineticsMetabolism

Identifiers

PMID32623139
PMCPMC7334458
OpenAlexW3037768000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.