ArticleNeuroImage. Clinical2020
Network reorganisation following anterior temporal lobe resection and relation with post-surgery seizure relapse: A longitudinal study.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Interictal and seizure-onset scalp electroencephalographic patterns in malformations of cortical development.Epilepsia · 2026Article
- Tractography-based correlation of diffusion anisotropy metrics in chronic post-stroke aphasia.BMC medical imaging · 2026Article
- Geometric representations of brain networks can predict the surgery outcome in temporal lobe epilepsy.NPJ systems biology and applications · 2025Article
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.Brain : a journal of neurology · 2025Review
- White matter quantitative anomalies and clinical outcome in drug-resistant epilepsies.Psychoradiology · 2025Article
- Neighbourhood topology unveils pathological hubs in the brain networks of epilepsy-surgery patients.Brain communications · 2025Article
- Long-term neuroplasticity in language networks after anterior temporal lobe resection.Epilepsia · 2025Article
- Association Between Postsurgical Functional Connectivity and Seizure Outcome in Patients With Temporal Lobe Epilepsy.Neurology · 2024Article
- Predictors of long-term memory and network connectivity 10 years after anterior temporal lobe resection.Epilepsia · 2024Article
- Indirect structural changes and reduced controllability after temporal lobe epilepsy resection.Epilepsia · 2024Article
- Progressive remodeling of structural networks following surgery for operculo-insular epilepsy.Frontiers in neurology · 2024Article
- Individualized epidemic spreading models predict epilepsy surgery outcomes: A pseudo-prospective study.Network neuroscience (Cambridge, Mass.) · 2024Article
- Immediate neural impact and incomplete compensation after semantic hub disconnection.Nature communications · 2023Article
- Remote effects of temporal lobe epilepsy surgery: Long-term morphological changes after surgical resection.Epilepsia open · 2023Article
- Article
- The role of epidemic spreading in seizure dynamics and epilepsy surgery.Network neuroscience (Cambridge, Mass.) · 2023Article
- World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.Molecular neurobiology · 2023Article
- Disentangling the Gordian Knot of Drug-Resistant Epilepsy.Epilepsy currents · 2021Article
- Structural Brain Network Abnormalities and the Probability of Seizure Recurrence After Epilepsy Surgery.Neurology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterise temporal lobe epilepsy (TLE) surgery-induced changes in brain network properties, as measured using diffusion weighted MRI, and investigate their association with postoperative seizure-freedom.
methodsFor 48 patients who underwent anterior temporal lobe resection, diffusion weighted MRI was acquired pre-operatively, 3-4 months post-operatively (N = 48), and again 12 months post-operatively (N = 13). Data for 17 controls were also acquired over the same period. After registering all subjects to a common space, we performed two complementary analyses of the subjects' quantitative anisotropy (QA) maps. 1) A connectometry analysis which is sensitive to changes in subsections of fasciculi. 2) A graph theory approach which integrates connectivity information across the wider brain network.
resultsWe found significant postoperative alterations in QA in patients relative to controls measured over the same period. Reductions were primarily located in the uncinate fasciculus and inferior fronto-occipital fasciculus ipsilaterally for all patients. Larger reductions were associated with postoperative seizure-freedom in left TLE. Increased QA was mainly located in corona radiata and corticopontine tracts. Graph theoretic analysis revealed widespread increases in nodal betweenness centrality, which were not associated with patient outcomes.
conclusionSubstantial alterations in QA occur in the months after epilepsy surgery, suggesting Wallerian degeneration and strengthening of specific white matter tracts. Greater reductions in QA were related to postoperative seizure freedom in left TLE.
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