ArticleChest2020
Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019.
Article in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis.Systematic reviews · 2023Pooled it
- Case Report: Rare co-occurrence of NMOSD and capillary leak syndrome treated with satralizumab.Frontiers in immunology · 2026Review
- Systemic capillary leak syndrome complicated by lower extremity compartment syndrome: a case report.JA clinical reports · 2025Article
- Clinical application of acute Q fever -induced systemic capillary leak syndrome in a patient by using metagenomic next-generation sequencing: a case report and literature review.BMC infectious diseases · 2025Review
- Successful management of coronavirus disease 2019-associated myocardial injury and capillary leak syndrome: A case report.ESC heart failure · 2024Article
- Fatal Systemic Capillary Leak Syndrome in a Patient with a COVID-19 Infection.Internal medicine (Tokyo, Japan) · 2024Article
- SARS-CoV-2 spike protein induces the cytokine release syndrome by stimulating T cells to produce more IL-2.Frontiers in immunology · 2024Article
- Pericardial effusion and systemic capillary leak syndrome late post-SARS-CoV-2 vaccination.BMJ case reports · 2023Article
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- Exacerbations of Idiopathic Systemic Capillary Leak Syndrome following BNT162b2 mRNA COVID-19 Vaccine (Pfizer-BioNTech).Internal medicine (Tokyo, Japan) · 2023Review
- Systemic Capillary Leak Syndrome (SCLS) Presentation in Patients Receiving Anti-cancer Treatments.Cureus · 2023Review
- Idiopathic systemic capillary leak syndrome: a case report.BMC nephrology · 2023Article
- COVID-19, Endothelium and the Cardiometabolic Patient: A Possible Role for Capillary Leak Syndrome.Biomedicines · 2022Review
- An unusual presentation of recurrent COVID-19 associated systemic capillary leak syndrome in a patient with multi-system inflammatory syndrome in adults (MIS-A) due to prior COVID-19 infection: Case report and literature review.Annals of medicine and surgery (2012) · 2022Article
- Limb Fasciotomy for COVID-19 Patients: Is the Chance to Cut a Chance to Cure?Plastic and reconstructive surgery. Global open · 2022Article
- Detailed videocapillaroscopic microvascular changes detectable in adult COVID-19 survivors.Microvascular research · 2022Article
- Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients.Journal of neuroinflammation · 2022Article
- Do we miss rare adverse events induced by COVID-19 vaccination?Frontiers in medicine · 2022Review
- Idiopathic Systemic Capillary Leak Syndrome: A Rare Cause of Refractory Shock Following Influenza B Infection.Journal of community hospital internal medicine perspectives · 2022Article
Corrections and comments
- Commented on by
- Commented on byResponse.2021
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.