Evidence map›Paper›PMID 32622750›Full record

ArticleTrends in biochemical sciences2020

Fungal Melanin Rewires Macrophage Metabolism.

Nicolas Papon, Jean-Pierre Gangneux, Yves Delneste

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Trends in biochemical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. A novel case of feline Exophiala spinifera disease in Americas: review integrating diagnosis and clinical.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Nicolas PaponHost-Pathogen Interaction Study Group (GEIHP) EA3142, Université d'Angers and Université de Brest, Angers, France; Interactions Cellulaires et Applications Thérapeutiques (ICAT), Structure Féderative de Recherche (SFR) 4208, Université d'Angers, Angers, France. Electronic address: nicolas.papon@univ-angers.fr.
Jean-Pierre GangneuxUniversité Rennes, Centre Hospitalier Universitaire (CHU) Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole des Hautes Études en Santé Publique (EHESP), Institut de Recherche en Santé, Environnement, et Travail (IRSET) Unité Mixte de Recherche (UMR) S1085, Rennes, France.
Yves DelnesteInteractions Cellulaires et Applications Thérapeutiques (ICAT), Structure Féderative de Recherche (SFR) 4208, Université d'Angers, Angers, France; Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), INSERM, Université de Nantes and Université d'Angers, Angers, France; CHU Angers, Département d'Immunologie Allergologie, Angers, France. Electronic address: yves.delneste@univ-angers.fr.
Centre Hospitalier Universitaire d'Angers · FRHôpital Pontchaillou · FRInteraction Hôtes Agents Pathogènes · FR

Funding

Medical Research Council MR/N006364/1
6 · The paper itself

Abstract

Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.

Indexed as

Antifungal AgentsMelaninsAspergillus fumigatusHumansMacrophagesSpores, FungalAntifungal AgentsMelaninsAspergillusfungal infectionsglycolysismacrophagesmelanin

Identifiers

PMID32622750
OpenAlexW3039865188

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.