Evidence map›Paper›PMID 32622509›Full record

ArticleAmerican journal of surgery2021

Breast conservation therapy versus mastectomy in the surgical management of invasive lobular carcinoma measuring 4 cm or greater.

Mary Kathryn Abel, Case E Brabham, Ruby Guo, Kelly Fahrner-Scott, Jasmine Wong, Michael Alvarado, Cheryl Ewing, Laura J Esserman, Rita A Mukhtar

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mary Kathryn AbelUniversity of California, San Francisco School of Medicine, San Francisco, CA, USA; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Case E BrabhamDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Ruby GuoDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Kelly Fahrner-ScottUniversity of California, San Francisco School of Medicine, San Francisco, CA, USA.
Jasmine WongDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Michael AlvaradoDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Cheryl EwingDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Laura J EssermanDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA.
Rita A MukhtarDepartment of Surgery, University of California, San Francisco, San Francisco, CA, USA. Electronic address: rita.mukhtar@ucsf.edu.
University of California, San Francisco · US

Funding

NRSA Training CoreTL1TR001871 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M., SOMSOUK, MA · 2016 to 2025
$10.1M
NCATS NIH HHS TL1 TR001871
6 · The paper itself

Abstract

backgroundThe safety of breast conservation therapy (BCT) has not been demonstrated in large ILC tumors, potentially contributing to the higher mastectomy rates seen in ILC.

methodsWe queried a prospectively maintained database to identify patients with ILC measuring ≥4 cm and evaluated difference in recurrence free survival (RFS) between those treated with BCT versus mastectomy using a multivariate model.

resultsOf 180 patients, 30 (16.7%) underwent BCT and 150 (83.3%) underwent mastectomy. Patients undergoing mastectomy were younger (56.6 vs. 64.3 years, p = 0.003) and had larger tumors (7.2 vs. 5.4 cm, p < 0.001). While tumor size, nodal stage, receptor subtype, and margin status were significantly associated with RFS, there was no difference in RFS at 5 (p = 0.88) or 10 (p = 0.65) years for individuals undergoing BCT versus mastectomy.

conclusionsFor patients with ILC ≥4 cm, BCT provides similar tumor control as mastectomy, provided that negative margins are achieved.

Indexed as

Mastectomy, SegmentalAdultAgedBreast NeoplasmsCarcinoma, LobularFemaleHumansMastectomyMiddle AgedRetrospective StudiesTumor BurdenBreast conservation surgeryInvasive lobular carcinomaLarge tumorsMastectomyRecurrence-free survival

Identifiers

PMID32622509
PMCPMC7736057
OpenAlexW3036543033

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.