Evidence map›Paper›PMID 32622369›Full record

ArticleDiagnostic pathology2020

Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases.

Elise R Venable, Sarah E Kerr, M Beatriz S Lopes, Karra A Jones, Andrew M Bellizzi, Taofic Mounajjed, Aditya Raghunathan, Oksana Hamidi, Thorvardur R Halfdanarson, Mabel Ryder and 1 more

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Article in Diagnostic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Elise R VenableDivision of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Sarah E KerrDivision of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
M Beatriz S LopesDepartment of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
Karra A JonesDepartment of Pathology, University of Iowa, Iowa City, IA, USA.
Andrew M BellizziDepartment of Pathology, University of Iowa, Iowa City, IA, USA.
Taofic MounajjedDivision of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Aditya RaghunathanDivision of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.
Oksana HamidiDivision of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Thorvardur R HalfdanarsonDivision of Medical Oncology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Mabel RyderDivision of Endocrinology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Rondell P GrahamDivision of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA. graham.rondell@mayo.edu.ORCID http://orcid.org/0000-0002-8686-4867
Mayo Clinic · USMayo Clinic in Arizona · USUniversity of Iowa · USUniversity of Virginia Health System · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
6 · The paper itself

Abstract

backgroundPathologists frequently encounter neuroendocrine tumors (NETs) presenting as multiple liver masses in routine practice. Most often, these are well-differentiated tumors with characteristic histologic features. In contrast, pituitary carcinoma is very rare, and there is limited data on its natural history and pathologic characterization.

methodsThe aim of this study was to describe clinical characteristics, histomorphology, immunophenotype and follow-up of pituitary carcinoma involving the liver and mimicking well-differentiated NETs of visceral origin. We selected a group of well-differentiated NETs of the pancreas to use as immunophenotypic controls. We identified 4 patients (age range, 51 to 73) with pituitary corticotroph carcinoma with liver metastases. Three patients presented with Cushing syndrome.

resultsAll cases histologically resembled well-differentiated NETs of visceral origin with Ki-67 proliferation indices of 5-42% and expression of T-PIT; metastatic tumors were not immunoreactive with CDX2, Islet 1 or TTF-1.

conclusionsFrequently, these cases display adrenocorticotropic hormone (ACTH) secretion and pituitary-specific transcription factor immunohistochemistry may be used as a reliable marker to distinguish metastatic pituitary carcinoma from NETs of visceral origin in addition to delineating a corticotroph carcinoma from somatotroph, lactotroph, thyrotroph, and gonadotroph lineage. Although rare, the differential diagnosis of pituitary carcinoma should be considered in metastatic well-differentiated NETs in which the site of origin is uncertain. In summary, pituitary corticotroph carcinoma can metastasize to the liver and mimic well-differentiated NET.

Indexed as

AgedBiomarkers, TumorDiagnosis, DifferentialFemaleHumansLiver NeoplasmsMaleMiddle AgedNeuroendocrine TumorsPituitary NeoplasmsBiomarkers, TumorCushing syndromeLiver metastasisNeuroendocrine tumorPituitary carcinomaPituitary tumor

Identifiers

PMID32622369
PMCPMC7335443
OpenAlexW3038856426

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.