Evidence map›Paper›PMID 32622314›Full record

ArticleNeuroImage. Clinical2020

Cerebral volume and diffusion MRI changes in children with sensorineural hearing loss.

Peter K Moon, Jason Z Qian, Emily McKenna, Kevin Xi, Nathan C Rowe, Nathan N Ng, Jimmy Zheng, Lydia T Tam, Sarah J MacEachern, Iram Ahmad and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Peter K MoonStanford University School of Medicine, Stanford, CA, USA.
Jason Z QianDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Emily McKennaDepartment of Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA.
Kevin XiDepartment of Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA.
Nathan C RoweDepartment of Radiology, University of Calgary, Calgary, Alberta, Canada.
Nathan N NgStanford University School of Medicine, Stanford, CA, USA.
Jimmy ZhengStanford University School of Medicine, Stanford, CA, USA.
Lydia T TamStanford University School of Medicine, Stanford, CA, USA.
Sarah J MacEachernDepartment of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Iram AhmadDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Alan G ChengDepartment of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, CA, USA.
Nils D ForkertDepartment of Radiology, University of Calgary, Calgary, Alberta, Canada.
Kristen W YeomDepartment of Radiology, Lucile Packard Children's Hospital, Stanford University, Stanford, CA, USA. Electronic address: kyeom@stanford.edu.
Stanford University · USUniversity of Calgary · CALucile Packard Children's Hospital · US

Funding

Clinician-scientist training program in otolaryngologyT32DC015209 · NIDCD · STANFORD UNIVERSITY · PI CHENG, ALAN GI-LUN · 2016 to 2021
$807k
NIDCD NIH HHS T32 DC015209
6 · The paper itself

Abstract

purposeSensorineural hearing loss (SNHL) is the most prevalent congenital sensory deficit in children. Information regarding underlying brain microstructure could offer insight into neural development in deaf children and potentially guide therapies that optimize language development. We sought to quantitatively evaluate MRI-based cerebral volume and gray matter microstructure children with SNHL. METHODS & MATERIALS: We conducted a retrospective study of children with SNHL who obtained brain MRI at 3 T. The study cohort comprised 63 children with congenital SNHL without known focal brain lesion or structural abnormality (33 males; mean age 5.3 years; age range 1 to 11.8 years) and 64 age-matched controls without neurological, developmental, or MRI-based brain macrostructure abnormality. An atlas-based analysis was used to extract quantitative volume and median diffusivity (ADC) in the following brain regions: cerebral cortex, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, brain stem, and cerebral white matter. SNHL patients were further stratified by severity scores and hearing loss etiology.

resultsChildren with SNHL showed higher median ADC of the cortex (p = .019), thalamus (p < .001), caudate (p = .005), and brainstem (p = .003) and smaller brainstem volumes (p = .007) compared to controls. Patients with profound bilateral SNHL did not show any significant differences compared to patients with milder bilateral SNHL, but both cohorts independently had smaller brainstem volumes compared to controls. Children with unilateral SNHL showed greater amygdala volumes compared to controls (p = .021), but no differences were found comparing unilateral SNHL to bilateral SNHL. Based on etiology for SNHL, patients with Pendrin mutations showed higher ADC values in the brainstem (p = .029, respectively); patients with Connexin 26 showed higher ADC values in both the thalamus (p < .001) and brainstem (p < .001) compared to controls.

conclusionSNHL patients showed significant differences in diffusion and volume in brain subregions, with region-specific findings for patients with Connexin 26 and Pendrin mutations. Future longitudinal studies could examine macro- and microstructure changes in children with SNHL over development and potential predictive role for MRI after interventions including cochlear implant outcome.

Indexed as

Cochlear ImplantsHearing Loss, SensorineuralWhite MatterChildChild, PreschoolDiffusion Magnetic Resonance ImagingHumansInfantMaleRetrospective StudiesConnexin 26DeafnessDiffusionDWIMRIPendrinSensorineural hearing lossVolume

Identifiers

PMID32622314
PMCPMC7334366
OpenAlexW3037578246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.