Evidence map›Paper›PMID 32621895›Full record

Observational studyAmerican journal of ophthalmology2020

Validation of a Compensation Strategy Used to Detect Choriocapillaris Flow Deficits Under Drusen With Swept Source OCT Angiography.

Yingying Shi, Zhongdi Chu, Liang Wang, Qinqin Zhang, William Feuer, Luis de Sisternes, Mary K Durbin, Giovanni Gregori, Ruikang K Wang, Philip J Rosenfeld

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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  9. The Impact of Carotid Endarterectomy on Choriocapillaris Perfusion.Investigative ophthalmology & visual science · 2023
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yingying ShiDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Zhongdi ChuDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Liang WangDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Qinqin ZhangDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
William FeuerDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Luis de SisternesResearch and Development, Carl Zeiss Meditec, Inc, Dublin, California, USA.
Mary K DurbinResearch and Development, Carl Zeiss Meditec, Inc, Dublin, California, USA.
Giovanni GregoriDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, Washington, USA.
Philip J RosenfeldDepartment of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address: prosenfeld@miami.edu.
University of Miami · USUniversity of Washington · USCarl Zeiss (United States) · US

Funding

Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
Ultra-wide field optical coherence tomography based angiography for imaging diabetic retinopathyR01EY028753 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2018 to 2021
$2.2M
NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
NEI NIH HHS P30 EY014801NEI NIH HHS R01 EY024158NEI NIH HHS R01 EY028753
6 · The paper itself

Abstract

purposeA compensation strategy that was developed to measure the choriocapillaris (CC) flow deficits (FDs) under drusen was tested in eyes with large drusen from age-related macular degeneration (AMD) before and after the drusen spontaneously resolved without evidence of disease progression.

designProspective, observational consecutive case series.

methodsPatients with AMD were enrolled in a prospective swept-source optical coherence tomography (SS-OCT) imaging study. Consecutive eyes with large drusen were followed, and eyes that underwent spontaneous collapse of drusen without evidence of disease progression were identified retrospectively. The drusen-resolved regions were manually outlined. CC FDs were measured using a previously published compensation strategy that adjusted for the decreased signal intensity underlying drusen. Both the percentage of FDs (FD%) and the mean FD sizes (MFDSs) were measured before and after drusen resolution.

resultsResolution of drusen was identified in 8 eyes from 8 patients. The average interval between the 2 visits was 7.8 months. The average drusen volumes measured between visits were 0.23 and 0.04 mm

conclusionsIn this naturally occurring experiment in which drusen collapsed without evidence of disease progression, the CC parameters were similar once our compensation strategy was applied both before and after the drusen resolved.

Indexed as

AgedChoroidDisease ProgressionFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMacular DegenerationMaleProspective StudiesRegional Blood FlowReproducibility of ResultsRetinal DrusenTomography, Optical Coherence

Identifiers

PMID32621895
PMCPMC8063776
OpenAlexW3039830594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.