Evidence map›Paper›PMID 32621874›Full record

Trial reportThe lancet. HIV2020

Efficacy of vitamin D

Christopher R Sudfeld, Ferdinand Mugusi, Alfa Muhihi, Said Aboud, Tumaini J Nagu, Nzovu Ulenga, Biling Hong, Molin Wang, Wafaie W Fawzi

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The lancet. HIV, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Efficacy of vitamin DAgeing research reviews · 2023
    Pooled it
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  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Review
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  16. Article
  17. Article
  18. The Costly Vicious Cycle of Infections and Malnutrition.The Journal of infectious diseases · 2024
    Review
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  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Christopher R SudfeldDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA. Electronic address: csudfeld@hsph.harvard.edu.
Ferdinand MugusiDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Alfa MuhihiManagement and Development for Health, Dar es Salaam, Tanzania.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Tumaini J NaguDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Nzovu UlengaManagement and Development for Health, Dar es Salaam, Tanzania.
Biling HongDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Molin WangDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Wafaie W FawziDepartment of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Harvard University · USMuhimbili University of Health and Allied Sciences · TZManagement and Development for Health · TZ

Funding

Trial of Vitamin D in HIV ProgressionR01DK098075 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2013 to 2017
$2.6M
NIDDK NIH HHS R01 DK098075
6 · The paper itself

Abstract

backgroundObservational data suggest that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis and mortality among people living with HIV. The primary aims of this study were to assess the effect of vitamin D

methodsThis was a randomised, double-blind, placebo-controlled trial of vitamin D

findingsBetween Feb 24, 2014, and Feb 24, 2017, 6250 adults initiating ART had serum 25-hydroxyvitamin D screening, 4000 of whom were enrolled in the trial and followed up for 1 year (follow-up of all participants was completed on March 7, 2018). 2001 patients were randomly assigned to the vitamin D

interpretationAdditional research is needed before vitamin D

fundingNational Institute of Diabetes and Digestive and Kidney Diseases.

Indexed as

AdultCholecalciferolDietary SupplementsDouble-Blind MethodFemaleHIV InfectionsHumansIncidenceIntention to Treat AnalysisKaplan-Meier EstimateMalePlacebosTanzaniaTreatment OutcomeTuberculosis, PulmonaryVitamin D25-hydroxyvitamin DCholecalciferolPlacebosVitamin D

Identifiers

PMID32621874
PMCPMC7433214
OpenAlexW3040226284

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.