Evidence map›Paper›PMID 32621851›Full record

Trial reportBiological psychology2020

Aversive perception in a threat context: Separate and independent neural activation.

Nicola Sambuco, Vincent D Costa, Peter J Lang, Margaret M Bradley

Abstract readClinical Trial
In one paragraph

Trial report in Biological psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Addiction biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Emotional Memory and Amygdala Activation.Frontiers in behavioral neuroscience · 2022
    Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicola SambucoCenter for the Study of Emotion and Attention, University of Florida, Gainesville, FL, United States. Electronic address: nsambuco@ufl.edu.
Vincent D CostaDepartment of Behavioral Neuroscience, Oregon Health & Science University, United States.
Peter J LangCenter for the Study of Emotion and Attention, University of Florida, Gainesville, FL, United States.
Margaret M BradleyCenter for the Study of Emotion and Attention, University of Florida, Gainesville, FL, United States.

Funding

Project 6: Individual Differences in the Motivational Substrates (pg 275)P50MH072850 · NIMH · UNIVERSITY OF FLORIDA · PI PRINCIPE, JOSE CARLOS · 2005 to 2009
$8.8M
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAINR01DE013956 · NIDCR · UNIVERSITY OF FLORIDA · PI BRADLEY, MARGARET M · 2001 to 2005
$981k
Cognitive Regulation and Reversal of Fear: Physiological and Neural MechanismsF31MH080551 · NIMH · UNIVERSITY OF FLORIDA · PI COSTA, VINCENT D · 2008 to 2010
$90k
NIDCR NIH HHS R01 DE013956NIMH NIH HHS F31 MH080551NIMH NIH HHS P50 MH072850
6 · The paper itself

Abstract

Unpleasant, compared to neutral, scenes reliably prompt enhanced functional brain activity in the amygdala and inferotemporal cortex. Considering data from psychophysiological studies in which defensive reactivity is further enhanced when viewing unpleasant scenes under threat of shock (compared to safety), the current study investigates functional activation in the amygdala-inferotemporal circuit when unpleasant (or neutral) scenes are viewed under threat of shock or safety. In this paradigm, a cue signaling threat or safety was presented in conjunction with either an unpleasant or neutral picture. Replicating previous studies, unpleasant, compared to neutral, scenes reliably enhanced activation in the amygdala and inferotemporal cortex. Functional activity in these regions, however, did not differ whether scenes were presented in a context threatening shock exposure, compared to safety, which instead activated regions of the anterior insula and cingulate cortex. Taken together, the data support a view in which neural regions activated in different defensive situations act independently.

Indexed as

AdolescentAmygdalaAvoidance LearningCerebral CortexElectric StimulationFemaleGyrus CinguliHumansNeuronsTemporal LobeVisual CortexAffective scenesAmygdalaAnterior insulafMRIThreat of shock

Identifiers

PMID32621851
PMCPMC7490760

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.