Evidence map›Paper›PMID 32621798›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2020

METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m

Lin Liu, Yu Wu, Qiuli Li, Jianfeng Liang, Qianting He, Luodan Zhao, Jianwen Chen, Maosheng Cheng, Zhexun Huang, Hui Ren and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 1 synthesis or guideline pooled it, 169 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. mStem cell research & therapy · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. METTL3-mediated mScientific reports · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. NClinical and translational medicine · 2025
    Article
  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Lin LiuDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Yu WuDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Qiuli LiDepartment of Head and Neck Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Jianfeng LiangDepartment of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou 510080, China.
Qianting HeDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Luodan ZhaoDepartment of Stomatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.
Jianwen ChenDepartment of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Maosheng ChengDepartment of Genetics, School of Life Science, Anhui Medical University, Anhui 230031, China.
Zhexun HuangDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Hui RenDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Jie ChenDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Liang PengDepartment of Oncology, Chinese PLA General Hospital, Beijing 100853, China.
Fengxin GaoGuangzhou Epibiotek Co., Ltd, Guangzhou 510700, China.
Demeng ChenDepartment of Otolaryngology, Center for Translational Medicine, Precision Medicine Institute, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: chendm29@mail.sysu.edu.cn.
Anxun WangDepartment of Oral and Maxillofacial Surgery, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China. Electronic address: anxunwang@yahoo.com.
Sun Yat-sen University · CNThe First Affiliated Hospital, Sun Yat-sen University · CNAnhui Medical University · CNChinese PLA General Hospital · CNState Key Laboratory of Oncology in South China

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA modification plays an essential function in regulating gene expression and diverse biological processes. RNA modification enzyme methyltransferase-like 3 (METTL3) affects tumor progression by regulating the N

Indexed as

AdenosineAnimalsBinding SitesCarcinoma, Squamous CellCell Line, TumorCell Transformation, NeoplasticEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMethylationMethyltransferasesMiceMouth NeoplasmsProtein BindingRNA, MessengerAdenosineMethyltransferasesMETTL3 protein, humanN-methyladenosineRNA, MessengerBMI1METTL3OSCCRNA modification

Identifiers

PMID32621798
PMCPMC7544972
OpenAlexW3037963954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.