Trial reportAddiction (Abingdon, England)2021
A pilot randomized controlled trial of assertive treatment including family involvement and home delivery of medication for young adults with opioid use disorder.
Trial report in Addiction (Abingdon, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Youth Opioid Recovery Support: A Developmentally-specific Intervention for Home Delivery of Extended Release Naltrexone
Expanding the Youth Opioid Recovery Support (YORS) Intervention for MOUD Adherence to Adolescents With OUD
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Do financial incentives increase mental health treatment engagement? A meta-analysis.Journal of consulting and clinical psychology · 2022Pooled it
- Evidence Base on Outpatient Behavioral Treatments for Adolescent Substance Use, Update 2018-2023: Current Status, Best Practices, and Opportunities for Advancing the Science.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- Extended-release naltrexone for youth with opioid use disorder.Journal of substance abuse treatment · 2021Trial
- Integrating Medications for Addiction Treatment into Assertive Community Treatment Teams: A Pilot Feasibility Study.Community mental health journal · 2026Article
- Family-centered interventions for people with substance use disorders in low-and middle-income country settings: a scoping review.The International journal on drug policy · 2026Article
- Development and Testing of a Peer Recovery Support Services Intervention for Retention on Medications for Opioid Use Disorder.Journal of addiction medicine · 2026Article
- Perceived Barriers to Care Among People Who Use Drugs in Vietnam.Drug and alcohol review · 2026Article
- Prevention and Management of Opioid use Disorder and Overdose in Adolescents and Young Adults.Current psychiatry reports · 2025Review
- Family caregivers of people who use drugs in Vietnam: Perceived burden and coping.Social science & medicine (1982) · 2025Article
- Impact Of Relationship Quality and Recovery Attitudes on Medication for Opioid Use Disorder Among Young Adults.Journal of drug issues · 2025Article
- Exploring the Determinants of Treatment Completion Among Youth Who Received Medication-Assisted Treatment in the United States.Healthcare (Basel, Switzerland) · 2025Article
- Lessons learned from concerned significant others: a qualitative analysis on involvement in services for young adult opioid use disorder.Frontiers in public health · 2025Article
- Risk of Relapse Following Discharge from Non-Hospital Residential Opioid Use Disorder Treatment: A Systematic Review of Studies Published from 2018 to 2022.Substance abuse and rehabilitation · 2025Review
- "I need as much support as I can get": A qualitative study of young adult perspectives on family involvement in treatment for opioid use disorder.Journal of substance use and addiction treatment · 2024Article
- Engagement, initiation, and retention in medication treatment for opioid use disorder among young adults: A narrative review of challenges and opportunities.Journal of substance use and addiction treatment · 2024Review
- An Assertive Community Intervention to Engage Youth with Opioid Use Disorder and Their Families.Child and adolescent psychiatric clinics of North America · 2024Review
- "Before medically advised" departure from hospital and subsequent drug overdose: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2024Article
- Provider perceptions of systems-level barriers and facilitators to utilizing family-based treatment approaches in adolescent and young adult opioid use disorder treatment.Addiction science & clinical practice · 2024Article
- An emergency-department-initiated outreach program for patients with opioid use disorder is associated with an increase in agonist therapy and engagement in addictions care: a one-year cohort study.Substance abuse treatment, prevention, and policy · 2024Article
- Linkage facilitation services for opioid use disorder: Taxonomy of facilitation practitioners, goals, and activities.Journal of substance use and addiction treatment · 2024Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsAlthough medications for opioid use disorder (OUD), including extended-release naltrexone (XR-NTX), have demonstrated effectiveness, adherence is often low. We tested the preliminary efficacy of youth opioid recovery support (YORS), a multi-component intervention designed to improve engagement and medication adherence for young adults with OUD.
designSingle-site randomized controlled trial with 24-week follow-up.
settingCommunity substance use disorder treatment program in Baltimore, MD, USA.
participantsYoung adults aged 18-26 years enrolled in inpatient/residential OUD treatment intending to pursue outpatient OUD treatment with XR-NTX. Twenty-one participants were randomized to YORS and 20 to treatment as usual (TAU). The analyzed sample was 65.8% male. INTERVENTION AND COMPARATOR: Components of YORS include: (1) home delivery of XR-NTX; (2) family engagement; (3) assertive outreach; and (4) contingency management for receipt of XR-NTX doses. The comparator was TAU, which consisted of a standard referral to outpatient care following an inpatient stay. MEASUREMENTS: Primary outcomes were number of XR-NTX doses received over 24 weeks and relapse to opioid use (defined as ≥ 10 days of use within 28 days) at 24 weeks.
findingsParticipants in the YORS condition received more XR-NTX doses [mean = 4.28; standard deviation (SD) = 2.3] compared with those in TAU (mean = 0.70; SD = 1.2), P < 0.01. Participants in the YORS group compared with TAU had lower rates of relapse (61 versus 95%; P < 0.01). Survival analyses revealed group differences on time to relapse with participants in TAU being more likely to relapse sooner compared with participants in the YORS condition [hazard ratio (HR) = 2.72, 95% confidence interval (CI) = 1.26-5.88, P < 0.01].
conclusionsThe youth opioid recovery support intervention for extended-release naltrexone adherence and opioid relapse prevention among young adults with opioid use disorder appeared to improve treatment and relapse outcomes compared with standard treatment.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.